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Antioxidant Capacity of 2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazoles

Antioxidant Capacity of 2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazoles

Authors :
Silvia Berlanga de Moraes Barros
Lucas Pizzuti
Pauline F. Rosales
Diogo Pineda Rivelli
Geonir M. Siqueira
Claudio M. P. Pereira
Frank H. Quina
S. P. Souza
Filipe A. N. Silva
Source :
Letters in Drug Design & Discovery. 7:657-660
Publication Year :
2010
Publisher :
Bentham Science Publishers Ltd., 2010.

Abstract

The antioxidant capacity of 2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazoles was evaluated. The values of antioxidant capacities of compounds 2d and 2e were found to be, respectively, 2,700 ± 150 and 3,135 ± 230 TE by the ORAC method, corresponding to a significant antioxidant capacity. recent publication, we reported the antioxidant capacity of phenylpyrazole using the ORAC method (14). In continua- tion of our research program, we report here the antioxidant evaluation of 2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)-4- phenylthiazoles, synthetic derivatives compounds of facile preparation (Scheme 1).

Details

ISSN :
15701808
Volume :
7
Database :
OpenAIRE
Journal :
Letters in Drug Design & Discovery
Accession number :
edsair.doi...........fa1b028e30a296ffaa5115aa0d3047c7
Full Text :
https://doi.org/10.2174/157018010792929513