A congener study of zileuton reveals interesting effects on glucuronidation rates

Authors :: Patricia Saavedra
Joseph M. Muchowski
Denise Yamamoto
Shahin Jamil-Panah
J. M. Young
David J. Morgans
Angel Guzman
Arthur F. Kluge
Francisco Xavier Talamas
Edvige Galeazzi
Philip Teitelbaum
Miguel Salazar
Source :: Bioorganic & Medicinal Chemistry Letters. 4:1437-1442
Publication Year :: 1994
Publisher :: Elsevier BV, 1994.
Abstract: Heteroatom substitution within the zileuton nucleus led to a congener series which was evaluated for potency and rate of glucuronidation, a major route for elimination of zileuton. Subtle changes in structure were found to significantly effect glucuronidation rate.

Subjects :: Chemistry
Stereochemistry
Organic Chemistry
Clinical Biochemistry
Glucuronidation
Pharmaceutical Science
Zileuton
Biochemistry
Congener
Drug Discovery
medicine
Molecular Medicine
Potency
Molecular Biology
medicine.drug

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