Effect of Insulin Treatment on the Mesangial Structure of KK Mice

In previous communications, we described specific glomerular changes in genetically diabetic KK mice (1–4). These changes include an increase in mesangial matrix and thickening of the glomerular basement membrane. Increase in the mesangium was found as early as two months of age, which gradually progressed with aging (3–4). Similar findings were described by other investigators.