Study on the preparation technology of Sanqi hemostatic spongia for percutaneous absorption

Objective: To optimize the preparation technology and matrix ratio of Sanqi hemostatic spongia. Methods: The effects of Twain 80, formaldehyde and twelve sodium alkyl sulfate on the matrix formability of the spongia were investigated by the L9 (33) orthogonal test, and the optimum ratio of the matrix was optimized through the water absorption, the thickness uniformity, the softness and the color degree. The orthogonal test results showed that the matrix ratio was Twain 80 1.4g, formaldehyde 1.6 mL, sodium dodecyl sulfate 1.0 g, and Sanqi hemostatic spongia was superior when the proportion of other substrates was fixed. Conclusion: Sanqi hemostatic spongia was produced by orthogonal test and matrix ratio is stable, uniform in thickness and good in quality.