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[Untitled]
- Source :
- Journal of Neurocytology. 29:209-213
- Publication Year :
- 2000
- Publisher :
- Springer Science and Business Media LLC, 2000.
-
Abstract
- Glial cell line-derived neurotrophic factor (GDNF), an important factor for developing and lesioned pre- and postganglionic sympathetic neurons, and its congeners signal through a receptor complex consisting of the tyrosine kinase c-Ret and a lipid-anchored alpha receptor (GFR alpha 1-4). Using in situ hybridization we show now that the mRNA for GFR alpha-2 is abundant in the adult rat adrenal medulla and its chromaffin cells. Coexpression of c-Ret and GFR alpha-1 mRNA's is restricted to a scarce subpopulation of medullary sympathetic neurons. Both GFR alpha-1 and GFR alpha-2 mRNA's are associated with preganglionic nerve trunks in the adrenal cortex. It is conceivable therefore that GDNF and related factors may activate chromaffin and preganglionic Schwann cells through a GFR-alpha receptor in absence of c-Ret.
- Subjects :
- endocrine system
medicine.medical_specialty
Receptor complex
Histology
biology
urogenital system
Adrenal cortex
General Neuroscience
Cell Biology
urologic and male genital diseases
medicine.anatomical_structure
Endocrinology
Nerve growth factor
nervous system
Proto-Oncogene Proteins c-ret
Neurotrophic factors
Internal medicine
medicine
Glial cell line-derived neurotrophic factor
biology.protein
Anatomy
Adrenal medulla
Tyrosine kinase
Subjects
Details
- ISSN :
- 03004864
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Journal of Neurocytology
- Accession number :
- edsair.doi...........fbde27b9d148e0de89736d4dc5b58bbc