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Treatment with Gaoziban Tablet Ameliorates Depression by Promoting GSK-3β Phosphorylation to Enhance the Wnt/β-catenin Activation in the Hippocampus of Rats

Authors :
Wan-Ci Song
Hai-Ping Li
Yang Luo
Yan-Wen Liu
Qiang Yin
Xin-Shuang Zou
He-Zhen Wu
Meng-Heng Wang
Wei-Liang Chen
Pengtao You
Yan-Fang Yang
Hanxiong Dan
Lei Shi
Jun-feng Zan
Hai-Long Yin
Source :
Journal of Exploratory Research in Pharmacology. :000-000
Publication Year :
2021
Publisher :
Xia & He Publishing, 2021.

Abstract

Depression is a severe and recurrent mental disease and contributes to the global disease burden. However, there are limited effective treatments for depression. This study evaluated the effect of a compound Gaoziban tablet (CGZBT) on depression and explored its potential mechanisms that underlie its action in rats.

Details

ISSN :
25725505
Database :
OpenAIRE
Journal :
Journal of Exploratory Research in Pharmacology
Accession number :
edsair.doi...........fc00761e9f3719e5339f58e1880f694e