Back to Search
Start Over
Chiral Bidentate Phosphoramidite-Pd Catalyzed Asymmetric Decarboxylative Dipolar Cycloaddition for Multistereogenic Tetrahydrofurans with Cyclic N-Sulfonyl Ketimine Moieties
- Source :
- Organic Letters. 23:4715-4720
- Publication Year :
- 2021
- Publisher :
- American Chemical Society (ACS), 2021.
-
Abstract
- An asymmetric [3 + 2] cycloaddition of vinyl ethylenecarbonates (VECs) and (E)-3-arylvinyl substituted benzo[d] isothiazole 1,1-dioxides has been developed using the Pd complex of a bidentate phosphoramidite (Me-BIPAM) as the catalyst, providing a wide variety of chiral multistereogenic vinyltetrahydrofurans in good yields with excellent diastereo- and enantioselectivities (up to >20:1 dr, 99% ee).
- Subjects :
- Sulfonyl
chemistry.chemical_classification
Isothiazole
Phosphoramidite
Denticity
010405 organic chemistry
Chemistry
Organic Chemistry
010402 general chemistry
01 natural sciences
Biochemistry
Medicinal chemistry
Cycloaddition
0104 chemical sciences
Catalysis
chemistry.chemical_compound
Physical and Theoretical Chemistry
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi...........fc391daace14cfd55feb9155e699f295