Acid Fluorides as Acyl Electrophiles in Suzuki-Miyaura Coupling

The first palladium-catalyzed construction of ketones via Suzuki-Miyaura reaction using acid fluorides is described. In contrast to typical acyl electrophiles such as acid chlorides, acid fluorides are uncommon acyl electrophiles to use in boron-based coupling probably due to a high level of stability toward nucleophiles. This first attempt to use acid fluorides as a coupling partner with boronic acid allowed highly functional group tolerance and a wide substrate scope, and afforded various ketones in effective yields.