ChemInform Abstract: Synthesis of Bis-heterocyclic Compounds with a Phenylene Bridge from 1,4- and 1,3-Bis(2-chloro-2-cyanovinyl)benzenes

Reaction of binucleophiles with 1,4- and 1,3-bis(2-chloro-2-cyanovinyl)benzenes, synthesized using a catalytic olefination of terephthalic and isophthalic aldehydes, gave high yields of aminopyrazoles, 3-amino-5-arylthiophene-2-carboxylic acid esters, and 2,4-diamino-6-arylpyrimidines.