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Diterpenoids from the Hainan Soft CoralSinularia parva
- Source :
- Helvetica Chimica Acta. 92:1341-1348
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Two new cembrane diterpenes, sinulaparvalides A and B (1 and 2, resp.), which contain an intriguing seven-membered lactone moiety, along with the four known related cembranoids 3-6, were isolated from the Hainan soft coral Sinularia parva. The structures of compounds I and 2 were established by spectroscopic methods, mainly on the basis of 2D-NMR techniques, and were confirmed by single-crystal X-ray diffraction analysis. The in vitro cytotoxic activities of these compounds were tested on human colon carcinoma (HCT-116), human promyelocytic leukemia (HL-60), and human lung carcinoma (A-549) tumor cell lines.
- Subjects :
- chemistry.chemical_classification
biology
Stereochemistry
Coral
Organic Chemistry
Tumor cells
biology.organism_classification
Biochemistry
Catalysis
Human lung
Inorganic Chemistry
medicine.anatomical_structure
chemistry
Drug Discovery
Cembrane Diterpenes
medicine
Physical and Theoretical Chemistry
Sinularia
Lactone
Human colon
Subjects
Details
- ISSN :
- 15222675 and 0018019X
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Helvetica Chimica Acta
- Accession number :
- edsair.doi...........fdfac9478ab19b5218bdd6826e3c312d