ChemInform Abstract: Suzuki Cross-Coupling of Arylboronic Acids Mediated by a Hydrosoluble Pd(0)/TPPTS Catalyst

Suzuki cross-coupling reactions between a range of aryl bromides and boronic acids using a water-soluble Pd(0)/TPPTS catalyst occur under mild conditions with high efficiency. The process tolerates electron-rich and electron-poor substituents and provides an efficient access to sterically hindered biaryls. Good turnovers are observed and the catalyst can be recycled three times without loss of activity.