Study of the Glycoregulation in the Obese Child

The glucose kinetics are modified in obese children. This fact does not appear after an intravenous load of glucose, but it may be disclosed when the penetration of glucose into the cells is forced either by the oral administration of a large amount of glucose or by the neous intravenous injection of glucose and of a supramaximal dose of insulin. The insulin response of the pancreas to oral glucose and intravenous tolbutamide is not significantly increased in obese children. The rise of the fasting level of free fattyacids is significant, but the response of adipose tissue to glucose is comparable to that observed in normal children.