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The utility of 2-[18F]FDG-PET/CT maximum SUV versus CT attenuation for directing bone biopsies
- Source :
- European Radiology. 31:6780-6792
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- This study aimed to compare the accuracy of PET/CT parameters with CT parameters for directing bone biopsies. The study was an IRB-approved retrospective study of 388 patients who underwent both 2-[18F] FDG PET/CT and CT within 6 weeks before a bone biopsy. Age, sex, cancer type, lesion length, SUVmax, tumor to liver (T/L) ratio, CT attenuation, difference in CT attenuation between the lesion and normal bone (delta CT attenuation), and the absolute delta CT attenuation were used as predictors. T tests and chi-squared tests were used to compare variables. DeLong’s test was used to compare receiver operator characteristic (ROC) curves. We reviewed the data from 388 patients. Of these, 295 patients had bone lesion biopsies, and 93 patients had bone marrow aspirations/biopsies. Biopsies of larger bone lesions (p = 0.033) and bone lesions with higher SUVmax (p = 0.005) were more likely to show malignancy. For bone lesions, the ROC curve for the SUVmax (AUC = 0.6827) was better than the ROC curves for delta CT attenuation (AUC = 0.5766, p = 0.032) and absolute delta CT attenuation (AUC = 0.5491, p = 0.006), but not significantly better than the ROC curves for CT attenuation (AUC = 0.5894, p = 0.061) and T/L ratio (AUC = 0.6778, p = 0.774). A threshold SUVmax of 5.25 had an accuracy of 0.713, sensitivity of 0.766, and specificity of 0.549 to predict malignancy in bone lesion biopsies. None of these variables predicted malignancy in bone marrow biopsies (p > 0.05 for all). Metabolic 2-[18F]FDG PET/CT parameters have more clinical impact for planning bone biopsies as compared to CT parameters. • The 2-[ 18 F]FDG PET/CT measurement (SUVmax) has more clinical impact for planning bone biopsies as compared to CT measurements. • Neither the change in CT attenuation of the lesion relative to normal bone nor the absolute value of this change was a significant predictor of malignancy. • 2-[ 18 F]FDG PET/CT may have clinical benefit and an additional role in directing bone biopsies.
- Subjects :
- medicine.medical_specialty
Receiver operating characteristic
medicine.diagnostic_test
business.industry
Ultrasound
Interventional radiology
General Medicine
Ct attenuation
Malignancy
medicine.disease
030218 nuclear medicine & medical imaging
Lesion
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
030220 oncology & carcinogenesis
Medicine
Radiology, Nuclear Medicine and imaging
Radiology
Bone marrow
medicine.symptom
business
Neuroradiology
Subjects
Details
- ISSN :
- 14321084 and 09387994
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- European Radiology
- Accession number :
- edsair.doi...........ff5a0f830090ac760b1ad417ff8658e1