Olanzapine-induced eccrine squamous syringometaplasia

Eccrine squamous syringometaplasia is a histopathologic pattern that has mainly been described in patients receiving chemo- therapy. Its association to nonchemotherapeutic agents is rare, with very few cases reported in the literature. We present the case of a 55-year-old patient with schizophrenia, who developed a skin erup- tion 5 weeks after initiating treatment with olanzapine. The histo- pathologic study revealed squamous syringometaplasia of the dermal eccrine ducts.