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Correlation between Clinical Factors and Prognosis in Newly Diagnosed Multiple Myeloma
- Source :
- Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 30(6)
- Publication Year :
- 2019
-
Abstract
- OBJECTIVE To explore the correlation between clinical factors and the prognosis of multiple myeloma (MM). STUDY DESIGN A cohort study. PLACE AND DURATION OF STUDY At the Third Affiliated Hospital of Inner Mongolia Medical University, Mongolia from January 2014 to December 2018. METHODOLOGY The clinical data of 81 patients with newly diagnosed MM were collected retrospectively. The correlation of prognosis with immunophenotype and (FISH) Fluorescence in situ hybridization was subjected to univariate and multivariate analyses. Overall and progression-free survival was determined. RESULTS The overall survival (OS) and progression-free survival (PFS) of patients with CD200+, CD81+, and CD27- were significantly shortened. CD200+ and CD27- were independent prognostic factors for OS and PFS in MM patients. The prognosis-related abnormal genes were analyzed, and univariate analysis revealed that OS and PFS were significantly shortened in patients with RB-1 deletion, CDKN2C deletion, and IGH rearrangement. CDKN2C deletion was an independent prognostic factor for OS and PFS in MM patients. CONCLUSION CDKN2C deletion is an independent prognostic factor of MM. CD200+ is an independent risk factor for poor prognosis of MM. Key Words: Multiple myeloma, Prognostic analysis, Fluorescence in situ hybridization, Immunity, Immunophenotype.
- Subjects :
- Oncology
medicine.medical_specialty
China
Multivariate analysis
In situ hybridization
030218 nuclear medicine & medical imaging
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Immunophenotyping
Internal medicine
medicine
Humans
Risk factor
Multiple myeloma
In Situ Hybridization, Fluorescence
Retrospective Studies
Univariate analysis
medicine.diagnostic_test
business.industry
General Medicine
medicine.disease
Prognosis
business
Multiple Myeloma
030217 neurology & neurosurgery
Cohort study
Fluorescence in situ hybridization
Subjects
Details
- ISSN :
- 16817168
- Volume :
- 30
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
- Accession number :
- edsair.doi.dedup.....001ed3dda005b1b9eeb435de838fcb56