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Bioelectronic control of chloride ions and concentration with Ag/AgCl contacts
- Source :
- APL Materials, Vol 8, Iss 9, Pp 091106-091106-7 (2020)
- Publication Year :
- 2020
- Publisher :
- AIP Publishing LLC, 2020.
-
Abstract
- Translation between ionic currents and measurable electronic signals is essential for the integration of natural systems and artificial bioelectronic devices. Chloride ions (Cl−) play a pivotal role in bioelectricity, and they are involved in several brain pathologies, including epilepsy and disorders of the autistic spectra, as well as cancer and birth defects. As such, controlling [Cl−] in solution can actively influence biochemical processes and can be used in bioelectronic therapies. Here, we demonstrate a bioelectronic device that uses Ag/AgCl contacts to control [Cl−] in solution by electronic means. We do so by exploiting the potential dependence of the reversible reaction, Ag + Cl− ↔ AgCl + e−, at the contact/solution interface, which is at the basis of the well-known Ag/AgCl reference electrode. In short, a negative potential on the Ag/AgCl contact transfers Cl− from the contact to the solution with increasing [Cl−] and vice versa. With this strategy, we demonstrate precise spatiotemporal control of [Cl−] in solution that can be used to affect physiological processes that are dependent on [Cl−]. As proof-of-concept, we use [Cl−] control to influence the membrane voltage on human pluripotent stem cells.
- Subjects :
- 010302 applied physics
Membrane potential
Materials science
lcsh:Biotechnology
Inorganic chemistry
General Engineering
Ionic bonding
02 engineering and technology
021001 nanoscience & nanotechnology
Brain pathologies
01 natural sciences
Chloride
Reference electrode
Reversible reaction
lcsh:QC1-999
Ion
lcsh:TP248.13-248.65
0103 physical sciences
Negative potential
medicine
General Materials Science
0210 nano-technology
lcsh:Physics
medicine.drug
Subjects
Details
- Language :
- English
- Volume :
- 8
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- APL Materials
- Accession number :
- edsair.doi.dedup.....0043993176c7f61dd8b23b6480de2660