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Update on mesenchymal stem cell therapies for cartilage disorders
- Source :
- World Journal of Orthopedics
- Publication Year :
- 2017
- Publisher :
- Baishideng Publishing Group Inc., 2017.
-
Abstract
- Cartilage disorders, including focal cartilage lesions, are among the most common clinical problems in orthopedic practice. Left untreated, large focal lesions may result in progression to osteoarthritis, with tremendous impact on the quality of life of affected individuals. Current management strategies have shown only a modest degree of success, while several upcoming interventions signify better outcomes in the future. Among these, stem cell therapies have been suggested as a promising new era for cartilage disorders. Certain characteristics of the stem cells, such as their potential to differentiate but also to support healing made them a fruitful candidate for lesions in cartilage, a tissue with poor healing capacity. The aim of this editorial is to provide an update on the recent advancements in the field of stem cell therapy for the management of focal cartilage defects. Our goal is to present recent basic science advances and to present the potential of the use of stem cells in novel clinical interventions towards enhancement of the treatment armamentarium for cartilage lesions. Furthermore, we highlight some thoughts for the future of cartilage regeneration and repair and to explore future perspectives for the next steps in the field.
- Subjects :
- 0301 basic medicine
Basic science
Cartilage disorder
medicine.medical_treatment
Adipose
Osteoarthritis
Bioinformatics
03 medical and health sciences
0302 clinical medicine
Chondral defect
medicine
Bone marrow
Orthopedics and Sports Medicine
030222 orthopedics
Stem cell
business.industry
Cartilage
Regeneration (biology)
Mesenchymal stem cell
Stem-cell therapy
medicine.disease
Management
Editorial
030104 developmental biology
medicine.anatomical_structure
Mesenchymal stem cells
business
Subjects
Details
- ISSN :
- 22185836
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- World Journal of Orthopedics
- Accession number :
- edsair.doi.dedup.....0049d19f27828a918a65bb0b6c4b66f0