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Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort
- Source :
- American Journal of Clinical Nutrition, 103(2), 454. American Society for Nutrition, Bakker, M F, Peeters, P HM, Klaasen, V M, Bueno-de-Mesquita, H B, Jansen, E HJM, Ros, M M, Travier, N, Olsen, A, Tjønneland, A, Overvad, K, Rinaldi, S, Romieu, I, Brennan, P, Boutron-Ruault, M-C, Perquier, F, Cadeau, C, Boeing, H, Aleksandrova, K, Kaaks, R, Kühn, T, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Vineis, P, Krogh, V, Panico, S, Masala, G, Tumino, R, Weiderpass, E, Skeie, G, Lund, E, Quirós, J R, Ardanaz, E, Navarro, C, Amiano, P, Sánchez, M-J, Buckland, G, Ericson, U, Sonestedt, E, Johansson, M, Sund, M, Travis, R C, Key, T J, Khaw, K-T, Wareham, N, Riboli, E & van Gils, C H 2016, ' Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort ', The American Journal of Clinical Nutrition, vol. 103, no. 2, pp. 454-64 . https://doi.org/10.3945/ajcn.114.101659
- Publication Year :
- 2014
-
Abstract
- BACKGROUND: Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity.OBJECTIVE: This study evaluated the associations of plasma carotenoid, retinol, tocopherol, and vitamin C concentrations and risk of breast cancer.DESIGN: In a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort, 1502 female incident breast cancer cases were included, with an oversampling of premenopausal (n = 582) and estrogen receptor-negative (ER-) cases (n = 462). Controls (n = 1502) were individually matched to cases by using incidence density sampling. Prediagnostic samples were analyzed for α-carotene, β-carotene, lycopene, lutein, zeaxanthin, β-cryptoxanthin, retinol, α-tocopherol, γ-tocopherol, and vitamin C. Breast cancer risk was computed according to hormone receptor status and age at diagnosis (proxy for menopausal status) by using conditional logistic regression and was further stratified by smoking status, alcohol consumption, and body mass index (BMI). All statistical tests were 2-sided.RESULTS: In quintile 5 compared with quintile 1, α-carotene (OR: 0.61; 95% CI: 0.39, 0.98) and β-carotene (OR: 0.41; 95% CI: 0.26, 0.65) were inversely associated with risk of ER- breast tumors. The other analytes were not statistically associated with ER- breast cancer. For estrogen receptor-positive (ER+) tumors, no statistically significant associations were found. The test for heterogeneity between ER- and ER+ tumors was statistically significant only for β-carotene (P-heterogeneity = 0.03). A higher risk of breast cancer was found for retinol in relation to ER-/progesterone receptor-negative tumors (OR: 2.37; 95% CI: 1.20, 4.67; P-heterogeneity with ER+/progesterone receptor positive = 0.06). We observed no statistically significant interaction between smoking, alcohol, or BMI and all investigated plasma analytes (based on tertile distribution).CONCLUSION: Our results indicate that higher concentrations of plasma β-carotene and α-carotene are associated with lower breast cancer risk of ER- tumors.
- Subjects :
- 0301 basic medicine
antioxidant
medicine.medical_treatment
Medicine (miscellaneous)
Physiology
Tocopherols
Ascorbic Acid
Antioxidants
Cohort Studies
chemistry.chemical_compound
0302 clinical medicine
Prospective Studies
Non-U.S. Gov't
Vitamin A
Carotenoid
2. Zero hunger
chemistry.chemical_classification
Nutrition and Dietetics
Tocopherol
Research Support, Non-U.S. Gov't
Retinol
carotenoids
Middle Aged
beta Carotene
3. Good health
European Prospective Investigation into Cancer and Nutrition
Neoplasm Proteins
Multicenter Study
Europe
Postmenopause
Receptors, Estrogen
030220 oncology & carcinogenesis
Cohort
Female
Case-Control Studie
Breast Neoplasm
Human
Adult
Risk
medicine.medical_specialty
Breast Neoplasms
Research Support
Follow-Up Studie
Neoplasm Protein
03 medical and health sciences
Breast cancer
breast cancer
Journal Article
medicine
Humans
plasma
Gynecology
Vitamin C
business.industry
Vitamin E
medicine.disease
Ascorbic acid
Carotenoids
Diet
Prospective Studie
030104 developmental biology
chemistry
Premenopause
Case-Control Studies
Cohort Studie
business
EPIC
Follow-Up Studies
Subjects
Details
- ISSN :
- 19383207 and 00029165
- Volume :
- 103
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The American journal of clinical nutrition
- Accession number :
- edsair.doi.dedup.....005523372b34869cc72a3fd053be5b73