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Multimodal cardiovascular magnetic resonance quantifies regional variation in vascular structure and function in patients with coronary artery disease: relationships with coronary disease severity
- Source :
- Journal of Cardiovascular Magnetic Resonance, Journal of Cardiovascular Magnetic Resonance, Vol 13, Iss 1, p 61 (2011), Europe PubMed Central
- Publication Year :
- 2011
-
Abstract
- Background Cardiovascular magnetic resonance (CMR) of the vessel wall is highly reproducible and can evaluate both changes in plaque burden and composition. It can also measure aortic compliance and endothelial function in a single integrated examination. Previous studies have focused on patients with pre-identified carotid atheroma. We define these vascular parameters in patients presenting with coronary artery disease and test their relations to its extent and severity. Methods and Results 100 patients with CAD [single-vessel (16%); two-vessel (39%); and three-vessel (42%) non-obstructed coronary arteries (3%)] were studied. CAD severity and extent was expressed as modified Gensini score (mean modified score 12.38 ± 5.3). A majority of carotid plaque was located in the carotid bulb (CB). Atherosclerosis in this most diseased segment correlated modestly with the severity and extent of CAD, as expressed by the modified Gensini score (R = 0.251, P < 0.05). Using the AHA plaque classification, atheroma class also associated with CAD severity (rho = 0.26, P < 0.05). The distal descending aorta contained the greatest plaque, which correlated with the degree of CAD (R = 0.222; P < 0.05), but with no correlation with the proximal descending aorta, which was relatively spared (R = 0.106; P = n. s.). Aortic distensibility varied along its length with the ascending aorta the least distensible segment. Brachial artery FMD was inversely correlated with modified Gensini score (R = -0.278; P < 0.05). In multivariate analysis, distal descending aorta atheroma burden, distensibility of the ascending aorta, carotid atheroma class and FMD were independent predictors of modified Gensini score. Conclusions Multimodal vascular CMR shows regional abnormalities of vascular structure and function that correlate modestly with the degree and extent of CAD.
- Subjects :
- Carotid Artery Diseases
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Brachial Artery
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
Severity of Illness Index
030218 nuclear medicine & medical imaging
Coronary artery disease
0302 clinical medicine
Medicine
Brachial artery
Aorta
Medicine(all)
Radiological and Ultrasound Technology
medicine.diagnostic_test
Middle Aged
Magnetic Resonance Imaging
Vasodilation
Carotid Arteries
England
Cardiology
cardiovascular system
Female
Radiology
Cardiology and Cardiovascular Medicine
Compliance
medicine.medical_specialty
Aortic Diseases
03 medical and health sciences
Predictive Value of Tests
medicine.artery
Internal medicine
Severity of illness
Humans
Radiology, Nuclear Medicine and imaging
cardiovascular diseases
Angiology
Aged
Analysis of Variance
Chi-Square Distribution
business.industry
Research
Magnetic resonance imaging
medicine.disease
Atherosclerosis
Compliance (physiology)
lcsh:RC666-701
Multivariate Analysis
business
Chi-squared distribution
Subjects
Details
- ISSN :
- 1532429X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
- Accession number :
- edsair.doi.dedup.....00671306965eeab2c8cb3d437b2d0ab7