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Thelarche variant: A new syndrome of precocious sexual maturation?
- Source :
- Acta Endocrinologica. 123:481-486
- Publication Year :
- 1990
- Publisher :
- Oxford University Press (OUP), 1990.
-
Abstract
- We describe 10 girls (mean age 3.7 years, range 1.9-6.9) with precocious sexual maturation and clinical findings intermediate between those of premature thelarche and central precocious puberty. Studies of spontaneous gonadotropin secretion and ovarian ultrasound morphology also revealed findings intermediate between those of isolated premature thelarche and central precocious puberty. There was no response in 6 of the girls treated with GnRH analogue, whether administered intranasally, sc, or by monthly depot injections. We have called this condition thelarche variant because the gonadotropin independence and cyclical nature of breast development may well be due to a lesion of folliculogenesis.
- Subjects :
- medicine.medical_specialty
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Puberty, Precocious
Buserelin
Pelvis
Follicle-stimulating hormone
Endocrinology
Internal medicine
medicine
Humans
Sexual maturity
Precocious puberty
Breast
Sexual Maturation
Thelarche
Child
Ultrasonography
Breast development
Bone Development
business.industry
Infant
Pubic Symphysis
Syndrome
General Medicine
Luteinizing Hormone
medicine.disease
Body Height
Gonadotropin secretion
Child, Preschool
Female
Follicle Stimulating Hormone
Gonadotropin
business
Luteinizing hormone
Pituitary Hormone-Releasing Hormones
Hair
Subjects
Details
- ISSN :
- 1479683X and 08044643
- Volume :
- 123
- Database :
- OpenAIRE
- Journal :
- Acta Endocrinologica
- Accession number :
- edsair.doi.dedup.....009a13edfb3c9614503f2d5f2f9dc9c8