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Association between genetic variants in the XPG gene and gastric cancer risk in a Southern Chinese population
- Source :
- Aging (Albany NY)
- Publication Year :
- 2016
- Publisher :
- Impact Journals LLC, 2016.
-
Abstract
- Xeroderma pigmentosum group G (XPG) recognizes and excises DNA damage on the 3' side during the DNA repair process. Previous studies indicated that XPG gene polymorphisms may associate with gastric cancer susceptibility, but results were inconsistent. We evaluated the association of five potentially functional XPG polymorphisms (rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C, and rs873601 G>A) with gastric cancer susceptibility in 1142 gastric cancer cases and 1173 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression models. Overall, no significant association was detected between any of selected polymorphism and gastric cancer risk. However, we found that individuals carrying 3-4 risk genotypes were at significantly higher risk of gastric cancer than those with 0-2 risk genotypes (OR=1.32, 95% CI=1.04-1.68, P=0.021). The stratification analysis revealed that the cumulative effect of risk genotypes (3-4 vs. 0-2) on gastric cancer were more prominent among subgroups older than 58 years and men. In conclusion, our results indicated that none of the selected XPG polymorphism could significantly alter gastric cancer susceptibility alone. These polymorphisms might collectively confer increased gastric cancer susceptibility. These findings would be strengthened by larger prospective multicenter studies involving different ethnic populations.
- Subjects :
- 0301 basic medicine
Oncology
Male
Aging
medicine.medical_specialty
China
Xeroderma pigmentosum
XPG
Genotype
DNA repair
Population
Biology
Bioinformatics
Polymorphism, Single Nucleotide
polymorphism
03 medical and health sciences
0302 clinical medicine
Polymorphism (computer science)
Stomach Neoplasms
Internal medicine
medicine
Genetic predisposition
Humans
education
education.field_of_study
gastric cancer
Cancer
Nuclear Proteins
Cell Biology
Odds ratio
Middle Aged
medicine.disease
Endonucleases
DNA-Binding Proteins
030104 developmental biology
030220 oncology & carcinogenesis
Female
Research Paper
genetic susceptibility
Transcription Factors
Subjects
Details
- Language :
- English
- ISSN :
- 19454589
- Volume :
- 8
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Aging (Albany NY)
- Accession number :
- edsair.doi.dedup.....009aac8210a1b28ae161dbad4a1490d2