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Correction to: Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression
- Source :
- Cell Death and Disease, Vol 13, Iss 1, Pp 1-2 (2021), Cell Death & Disease
- Publication Year :
- 2021
- Publisher :
- Nature Publishing Group, 2021.
-
Abstract
- Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through its positive regulation of DEPDC1 expression. Mechanistically, Linc-ROR acts as competing endogenous RNA to stabilize DEPDC1 mRNA and regulates DEPDC1 mRNA stability by binding HNRNPK. Thus, these findings suggest that function of Linc-ROR-mediated DEPDC1 could predispose hepatocellular carcinoma patients to progression and angiogenesis, and may serve as a potential target for anticancer therapies.
- Subjects :
- Male
Cancer Research
Carcinoma, Hepatocellular
Epithelial-Mesenchymal Transition
Carcinogenesis
Immunology
Mice, Nude
Heterogeneous-Nuclear Ribonucleoprotein K
Gastrointestinal cancer
Cellular and Molecular Neuroscience
Cell Line, Tumor
Human Umbilical Vein Endothelial Cells
Animals
Humans
Neoplasm Invasiveness
RNA, Messenger
Cancer
Cell Proliferation
Mice, Inbred BALB C
Base Sequence
Neovascularization, Pathologic
QH573-671
GTPase-Activating Proteins
Liver Neoplasms
Correction
Cell Biology
Middle Aged
Neoplasm Proteins
Up-Regulation
Gene Expression Regulation, Neoplastic
MicroRNAs
Disease Progression
Female
RNA, Long Noncoding
Cytology
Protein Binding
Subjects
Details
- Language :
- English
- ISSN :
- 20414889
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cell Death and Disease
- Accession number :
- edsair.doi.dedup.....00a35305d9e4518defa4341353a3f425