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Correction to: Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression

Authors :
Tian, Chuan
Abudoureyimu, Mubalake
Lin, Xinrong
Chu, Xiaoyuan
Wang, Rui
Source :
Cell Death and Disease, Vol 13, Iss 1, Pp 1-2 (2021), Cell Death & Disease
Publication Year :
2021
Publisher :
Nature Publishing Group, 2021.

Abstract

Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through its positive regulation of DEPDC1 expression. Mechanistically, Linc-ROR acts as competing endogenous RNA to stabilize DEPDC1 mRNA and regulates DEPDC1 mRNA stability by binding HNRNPK. Thus, these findings suggest that function of Linc-ROR-mediated DEPDC1 could predispose hepatocellular carcinoma patients to progression and angiogenesis, and may serve as a potential target for anticancer therapies.

Details

Language :
English
ISSN :
20414889
Volume :
13
Issue :
1
Database :
OpenAIRE
Journal :
Cell Death and Disease
Accession number :
edsair.doi.dedup.....00a35305d9e4518defa4341353a3f425