RESEARCHES ON ANTIVIRAL AGENTS .2. ENANTIOSPECIFIC SYNTHESIS OF 1,3-DIMETHYL-6-OXIRANYLPYRIMIDIN-2,4-DIONE WITH ANTI-ASFV ACTIVITY

Chiral epoxide (+) 2 has been synthesized in very good yield and high enantiomeric excess via a modified Solladie procedure starting from commercially available orotic acid. Chiral HPLC chromatographic analysis and 300 MHz 1H-NMR with the addition of chiral shift reagent Eu(hfc)3 of compound (+) 2 are also reported.