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COVID-19 Disease and Hypercoagulability Leading to Acute Ischemic Stroke
- Source :
- Neurohospitalist
- Publication Year :
- 2020
- Publisher :
- SAGE Publications, 2020.
-
Abstract
- Introduction: SARS-Coronavirus-2 infection leading to COVID-19 disease presents most often with respiratory failure. The systemic inflammatory response of SARS-CoV-2 along with the hypercoagulable state that the infection elicits can lead to acute thrombotic complications including ischemic stroke. We present 3 cases of patients with COVID-19 disease who presented with varying degrees of vascular thrombosis. Cases: Cases 1 and 2 presented as cerebral ischemic strokes without respiratory failure. Given their exposure risks, they were both tested for COVID-19 disease. Case 2 ultimately developed respiratory failure and pulmonary embolism. Cases 2 and 3 were found to have simultaneous arterial and venous thromboembolism (ischemic stroke and pulmonary embolism) as well as positive antiphospholipid antibodies. Conclusion: Our case series highlight the presence of hypercoagulability as an important mechanism in patients with COVID-19 disease with and without respiratory failure. Despite arterial and venous thromboembolic events, antiphospholipid and hypercoagulable panels in the acute phase can be difficult to interpret in the context of acute phase response and utilization of thrombolytics. SARS-CoV-2 testing in patients presenting with stroke symptoms may be useful in communities with a high case burden or patients with a history of exposure.
- Subjects :
- medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
business.industry
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Inflammatory response
Disease
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Short Reports
Respiratory failure
Internal medicine
medicine
Cardiology
Neurology (clinical)
business
Acute ischemic stroke
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 19418752 and 19418744
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- The Neurohospitalist
- Accession number :
- edsair.doi.dedup.....00c03a06a4f3d49a2754d7f184c40047