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Elevated Levels of miR-155 in Blood and Urine from Patients with Nephrolithiasis

Authors :
Min Liu
Jun-Hua Zheng
Xudong Yao
Yunfei Xu
Yangyang Hu
Bo Peng
Weida Dong
Source :
BioMed Research International, BioMed Research International, Vol 2014 (2014)
Publication Year :
2014
Publisher :
Hindawi Limited, 2014.

Abstract

Background.Both circulating and urinary miRNAs may represent a potential noninvasive molecular biomarker capable of predicting chronic kidney disease, and, in the present study, we will investigate the serum and urinary levels of miR-155 in patients with nephrolithiasis.Methods.Serum and urinary levels of miR-155 are quantified in 60 patients with nephrolithiasis; the result was compared to 50 healthy volunteers. Estimated glomerular filtration (eGFR) was calculated and, by simple regression analysis, the correlations of miR-155/eGFR and miR-155/CRP (C-reactive protein) levels were analyzed as well.Results.The median levels of serum and urinary levels of miR-155 are significantly higher in nephrolithiasis patients than in controls. eGFR inversely correlates with urinary level of miR-155; CRP positively correlates with urinary miR-155. Urinary level of miR-155 inversely correlates with urinary expression of interleukin- (IL-) 1β, IL-6, and tumor necrosis factor- (TNF-)αand positively correlates with urinary expression of regulated upon activation, normal T-cell expressed, and secreted (RANTES).Conclusion.Serum and urinary levels of miR-155 were significantly elevated in patients with nephrolithiasis, and the upregulation of miR-155 was correlated with decline of eGFR and elevation of CRP. Our results suggested that miR-155 might play important roles in the pathophysiology of nephrolithiasis via regulating inflammatory cytokines expression. Further study on the molecular pathogenic mechanism and larger scale of clinical trial are required.

Details

ISSN :
23146141 and 23146133
Volume :
2014
Database :
OpenAIRE
Journal :
BioMed Research International
Accession number :
edsair.doi.dedup.....00ca3041d1ac2e50083daae5d7423b3b