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Assessment of Cow’s milk-related symptom scores in early identification of cow’s milk protein allergy in Chinese infants
- Source :
- BMC Pediatrics, Vol 19, Iss 1, Pp 1-7 (2019), BMC Pediatrics
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background The diagnosis of cow’s milk protein allergy(CMPA) may be easily misdiagnosed due to its lack of specific symptoms. Thus, experts have proposed the use of Cow’s milk-related symptom scores (CoMiSS) to predict CMPA. There has been no relevant report on the clinical application value of CoMiSS in Chinese children. This study aimed to evaluate the effect of CoMiSS in early identification of CMPA in Chinese infants. Methods We calculated CoMiSS for 38 infants with suspected CMPA diagnosed in the pediatric gastroenterologic clinic in our hospital. After 4 weeks of dietary elimination and symptomatic improvement, these infants returned to our hospital to undergo oral food challenge (OFC). The ROC curve was used to determine the sensitivity and specificity of CoMiSS and evaluate the effect of CoMiSS in early identification of CMPA in Chinese infants. We didn’t determine the CoMiSS of presumed healthy infants as control group. Results Of 38 infants who underwent OFC testing, the average CoMiSS of infants with positive OFC testing was 7.4 ± 2.3, while the average CoMiSS of infants with negative OFC testing was 4.1 ± 1.6, and there was a significant difference between two groups(F = 2.13, P
- Subjects :
- Male
China
Pediatrics
medicine.medical_specialty
Allergy
Sensitivity and Specificity
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Animals
Humans
Medicine
Prospective Studies
030212 general & internal medicine
Child
Milk protein
Oral food challenge
business.industry
Significant difference
lcsh:RJ1-570
Infant
lcsh:Pediatrics
Milk Proteins
medicine.disease
Bloody
ROC Curve
CoMiSS allergy food allergy food hypersensitivity Oral food challenge infant
Cow's milk protein
Area Under Curve
Case-Control Studies
Child, Preschool
Pediatrics, Perinatology and Child Health
Cattle
Female
Milk Hypersensitivity
Symptom Assessment
business
Area under the roc curve
Research Article
Subjects
Details
- ISSN :
- 14712431
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- BMC Pediatrics
- Accession number :
- edsair.doi.dedup.....0117a68b7242b5b3699dc4e58f04f66c