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Baicalin Suppresses Migration, Invasion and Metastasis of Breast Cancer via p38MAPK Signaling Pathway
- Source :
- Anti-Cancer Agents in Medicinal Chemistry. 13:923-931
- Publication Year :
- 2013
- Publisher :
- Bentham Science Publishers Ltd., 2013.
-
Abstract
- Metastasis is the major cause of death in breast cancer patients. In this study, we investigated the effects of baicalin, a natural compound, on cell migration, invasion and metastasis using human breast cancer MDA-MB-231 cell line as model system. Baicalin not only dose-dependently inhibited MDA-MB-231 cells migration and in vitro invasion, but also suppressed the tumor outgrowth and the pulmonary metastasis of MDA-MB-231 cells in xenograft model. Importantly, treatment of baicalin caused little change in body weight, liver and kidney function of recipient animals. Tumorigenesis-inhibitory effect is likely linked to the capability of baicalin to downregulate metalloproteinase (MMP)-2, MMP-9, urokinase-type plasminogen activator (uPA) and uPA receptor (uPAR) expression in MDA-MB-231 cells. As baicalin blocked p38 mitogen-activated protein kinase (MAPK) activity and treatment of p38MAPK inhibitor SB203580 led to the reduction of MMP-2, MMP-9, uPA and uPAR expressions, we concluded that baicalin suppresses the tumorigenecity of MDA-MB-231 cells by down-regulating MMP-2, MMP-9, uPA and uPAR expressions through the interruption of p38MAPK signaling pathway.
- Subjects :
- MAPK/ERK pathway
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Mice, Nude
Breast Neoplasms
Matrix metalloproteinase
p38 Mitogen-Activated Protein Kinases
Metastasis
Mice
chemistry.chemical_compound
Cell Movement
Cell Line, Tumor
Internal medicine
medicine
Animals
Humans
Neoplasm Invasiveness
Breast
Enzyme Inhibitors
skin and connective tissue diseases
Lung
Flavonoids
Pharmacology
Chemistry
Cancer
Cell migration
medicine.disease
Antineoplastic Agents, Phytogenic
Urokinase receptor
Endocrinology
Cancer research
Molecular Medicine
Female
Signal transduction
Baicalin
Drugs, Chinese Herbal
Scutellaria baicalensis
Signal Transduction
Subjects
Details
- ISSN :
- 18715206
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Anti-Cancer Agents in Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....0132b39732d97649c42a2579c865c2be