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Early Detection and Quantification of Cerebral Venous Thrombosis by Magnetic Resonance Black-Blood Thrombus Imaging
- Source :
- Stroke. 47:404-409
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- Background and Purpose— Early diagnosis of cerebral venous thrombosis (CVT) is currently a major clinical challenge. We proposed a novel magnetic resonance black-blood thrombus imaging technique (MRBTI) for detection and quantification of CVT. Methods— MRBTI was performed on 23 patients with proven CVT and 24 patients with negative CVT confirmed by conventional imaging techniques. Patients were divided into 2 groups based on the duration of clinical onset: ≤7 days (group 1) and between 7 and 30 days (group 2). Signal/noise ratio was calculated for the detected thrombus, and contrast/noise ratio was measured between thrombus and lumen and also between thrombus and brain tissue. The feasibility of using MRBTI for thrombus volume measurement was explored, and total thrombus volume was calculated for each patient. Results— In 23 patients with proven CVT, MRBTI correctly identified 113 of 116 segments with a sensitivity of 97.4%. Thrombus signal/noise ratio was 153±57 and 261±95 for group 1 (n=10) and group 2 (n=13), respectively ( P P Conclusions— The current findings support that with effectively suppressed blood signal, MRBTI allows selective visualization of thrombus as opposed to indirect detection of venous flow perturbation and can be used as a promising first-line diagnostic imaging tool.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Signal-To-Noise Ratio
Sensitivity and Specificity
Article
Magnetic resonance angiography
030218 nuclear medicine & medical imaging
Cohort Studies
Sinus Thrombosis, Intracranial
Young Adult
03 medical and health sciences
Imaging, Three-Dimensional
0302 clinical medicine
medicine
Medical imaging
Humans
Prospective Studies
Thrombus
Child
Prospective cohort study
Aged
Aged, 80 and over
Venous Thrombosis
Advanced and Specialized Nursing
medicine.diagnostic_test
business.industry
Brain
Magnetic resonance imaging
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Cerebral Angiography
Venous thrombosis
Early Diagnosis
Intracranial Thrombosis
Case-Control Studies
Child, Preschool
Female
Neurology (clinical)
Radiology
Tomography, X-Ray Computed
Cardiology and Cardiovascular Medicine
business
Magnetic Resonance Angiography
030217 neurology & neurosurgery
Cerebral angiography
Subjects
Details
- ISSN :
- 15244628 and 00392499
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Stroke
- Accession number :
- edsair.doi.dedup.....016c832fd5091491f5d8e5a2d82032ec