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Prospective Randomized Trial of Early Versus Late Enteral Iron Supplementation in Infants With a Birth Weight of Less Than 1301 Grams
- Source :
- Pediatrics. 106:700-706
- Publication Year :
- 2000
- Publisher :
- American Academy of Pediatrics (AAP), 2000.
-
Abstract
- Objectives. To examine whether early enteral iron supplementation (EI) would improve serum ferritin as a measure of nutritional iron status at 2 months of age and would prevent definite iron deficiency (ID) in infants with a birth weight of Methods. Infants were randomly assigned to receive enteral iron supplementation of 2 to 6 mg/kg/day as soon as enteral feedings of >100 mL/kg/day were tolerated (EI) or at 61 days of life (late enteral iron supplementation [LI]). Nutritional iron status was assessed: 1) at birth, 2) at 61 days of life, 3) when the infants reached a weight of 1.6 times birth weight, and 4) before blood was transfused at a hematocrit of 50% one week after the onset of enteral iron supplementation. Restrictive red cell transfusion guidelines were followed and all transfusions were documented. Erythropoietin was not administered. The primary outcome variables were: 1) ferritin at 61 days and 2) the number of infants with ID. Results. Ferritin at 61 days was not different between the groups. Infants in the LI group were more often iron-deficient (26/65 vs 10/68) and received more blood transfusions after day 14 of life. No adverse effects of EI were noted. Conclusions. EI is feasible and probably safe in infants with birth weight
- Subjects :
- Pediatrics
medicine.medical_specialty
Blood transfusion
Iron
medicine.medical_treatment
Birth weight
Nutritional Status
Enteral administration
Drug Administration Schedule
Enteral Nutrition
medicine
Humans
Prospective Studies
biology
business.industry
Infant, Newborn
Infant
Iron Deficiencies
Iron deficiency
Infant, Low Birth Weight
medicine.disease
Ferritin
Low birth weight
Blood chemistry
Iron-deficiency anemia
Ferritins
Pediatrics, Perinatology and Child Health
biology.protein
medicine.symptom
business
Subjects
Details
- ISSN :
- 10984275 and 00314005
- Volume :
- 106
- Database :
- OpenAIRE
- Journal :
- Pediatrics
- Accession number :
- edsair.doi.dedup.....016f84d5353b0a99e6158955be36ce0c
- Full Text :
- https://doi.org/10.1542/peds.106.4.700