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An original inner ear neuroepithelial degeneration in a deaf Rottweiler puppy
- Source :
- Hearing Research. 161:65-71
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- Histopathological investigation was conducted on both inner ears from a 4.5-month-old Rottweiler puppy with electrophysiologically confirmed bilateral deafness. The lesions were restricted to the organ of Corti and spiral ganglion that both displayed severe degenerative changes. The outer hair cells were less affected than the inner hair cells. The number of spiral ganglion neurons was reduced, and remaining neurons were altered. The basal and middle cochlear turns were more affected than the apical one. The vestibules were normal. Immunostaining with calbindin, calretinin, S100A1 and S100A6 polyclonal antisera was helpful in identifying different cell-types in the degenerated cochlea. The early and severe spiral ganglion cell degeneration is an uncommon finding no matter the species. Such lesions bear significance within the frame of cochlear implants technology for deaf infants.
- Subjects :
- Pathology
medicine.medical_specialty
Hearing loss
Deafness
Biology
Dogs
otorhinolaryngologic diseases
medicine
Animals
Inner ear
Dog Diseases
Organ of Corti
Spiral ganglion
Cochlea
Anatomy
Immunohistochemistry
Sensory Systems
Neuroepithelial cell
medicine.anatomical_structure
nervous system
Ear, Inner
Nerve Degeneration
sense organs
medicine.symptom
Calretinin
Spiral Ganglion
Rottweiler
Subjects
Details
- ISSN :
- 03785955
- Volume :
- 161
- Database :
- OpenAIRE
- Journal :
- Hearing Research
- Accession number :
- edsair.doi.dedup.....01707fa1645abe4155e451f371cf21c8