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Cytotoxic 1,3-Thiazole and 1,2,4-Thiadiazole Alkaloids from Penicillium oxalicum: Structural Elucidation and Total Synthesis
- Source :
- Molecules; Volume 21; Issue 3; Pages: 232, Molecules, Vol 21, Iss 3, p 232 (2016), Molecules
- Publication Year :
- 2016
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2016.
-
Abstract
- Two new thiazole and thiadiazole alkaloids, penicilliumthiamine A and B (2 and 3), were isolated from the culture broth of Penicillium oxalicum, a fungus found in Acrida cinerea. Their structures were elucidated mainly by spectroscopic analysis, total synthesis and X-ray crystallographic analysis. Biological evaluations indicated that compound 1, 3a and 3 exhibit potent cytotoxicity against different cancer cell lines through inhibiting the phosphorylation of AKT/PKB (Ser 473), one of important cancer drugs target.
- Subjects :
- Penicillium oxalicum
alkaloids
total synthesis
structure elucidation
cytotoxicity
Cell Survival
Stereochemistry
Gene Expression
Pharmaceutical Science
Antineoplastic Agents
Grasshoppers
Crystallography, X-Ray
010402 general chemistry
01 natural sciences
Acrida cinerea
Article
Analytical Chemistry
lcsh:QD241-441
chemistry.chemical_compound
lcsh:Organic chemistry
Thiadiazoles
Cell Line, Tumor
Drug Discovery
Animals
Humans
Physical and Theoretical Chemistry
Cytotoxicity
Thiazole
Protein kinase B
Molecular Structure
biology
Cytotoxins
010405 organic chemistry
Organic Chemistry
Penicillium
Total synthesis
biology.organism_classification
0104 chemical sciences
Thiazoles
Biochemistry
chemistry
Chemistry (miscellaneous)
Molecular Medicine
Phosphorylation
Proto-Oncogene Proteins c-akt
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Database :
- OpenAIRE
- Journal :
- Molecules; Volume 21; Issue 3; Pages: 232
- Accession number :
- edsair.doi.dedup.....01772acd976349cf91d13f6d5d86e57e
- Full Text :
- https://doi.org/10.3390/molecules21030232