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Assessing the periprocedural magnitude of platelet count change in response to lusutrombopag
- Source :
- JHEP Reports, JHEP Reports, Vol 3, Iss 2, Pp 100228-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Background & Aims Despite limitations, platelet transfusion has been used to minimise bleeding risk in patients with thrombocytopaenia. Lusutrombopag is an oral, thrombopoietin receptor agonist approved for treatment of thrombocytopaenia associated with chronic liver disease in patients undergoing planned invasive procedures. This post-hoc analysis assessed the magnitude of platelet count change based on the integrated per-protocol population from 2 similar phase III multicentre, randomised, double-blind, placebo-controlled trials. Methods Adults with chronic liver disease-induced thrombocytopaenia and platelet count<br />Graphical abstract<br />Highlights • Thrombocytopaenia is common in patients with chronic liver disease. • Lusutrombopag increased platelet count ≥1.5-fold in most patients with chronic liver disease-induced thrombocytopaenia. • Lusutrombopag doubled platelet count in half of patients treated. • Lusutrombopag-induced platelet count increases (without platelet transfusion) lasted for 3 weeks.
- Subjects :
- Thrombocytopaenia
medicine.medical_specialty
Procedural
PP, per protocol
PBO, placebo
Population
GCP, Good Clinical Practice
CT, computerised tomography
Chronic liver disease
Placebo
WHO, World Health Organization
ICH, International Conference on Harmonisation
Internal medicine
LUSU, lusutrombopag
Internal Medicine
medicine
ICF, informed consent form
Immunology and Allergy
Platelet
lcsh:RC799-869
Adverse effect
education
education.field_of_study
Intention-to-treat analysis
Hepatology
business.industry
US, ultrasonography
Hazard ratio
ITT, intention-to-treat
TCP, thrombocytopaenia
Gastroenterology
Magnitude
medicine.disease
HR, hazard ratio
Lusutrombopag
Platelet transfusion
PT, platelet transfusion
CLD, chronic liver disease
lcsh:Diseases of the digestive system. Gastroenterology
business
AE, adverse event
MRI, magnetic resonance imaging
Research Article
TEAE, treatment-emergent adverse event
Subjects
Details
- Language :
- English
- ISSN :
- 25895559
- Volume :
- 3
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- JHEP Reports
- Accession number :
- edsair.doi.dedup.....0179199a2371e936972820821eea2ee5