Back to Search
Start Over
Effect of folic acid on prenatal alcohol-induced modification of brain proteome in mice
- Source :
- British Journal of Nutrition. 99:455-461
- Publication Year :
- 2008
- Publisher :
- Cambridge University Press (CUP), 2008.
-
Abstract
- Maternal alcohol consumption during pregnancy can induce central nervous system abnormalities in the fetus, and folic acid supplementation can reverse some of the effects. The objective of the present study was to investigate prenatal alcohol exposure-induced fetal brain proteome alteration and the protective effect of folic acid using proteomic techniques. Alcohol (5·0 g/kg) was given intragastrically from gestational day (GD) 6 to15, with or without 60·0 mg folic acid/kg given intragastrically during GD1–16 to pregnant Balb/c mice. The control group received distilled water only. Results of litter evaluation on GD18 showed that supplementation of folic acid reversed the prevalence of microcephaly induced by alcohol. Proteomic analysis indicated that, under the dosage of the present investigation, folic acid mainly reversed the alcohol-altered proteins involved in energy production, signal pathways and protein translation, which are all important for central nervous system development.
- Subjects :
- medicine.medical_specialty
Proteome
Central nervous system
Fetal alcohol syndrome
Medicine (miscellaneous)
Nerve Tissue Proteins
Alcohol
Prenatal care
Eating
Mice
chemistry.chemical_compound
Folic Acid
Pregnancy
Internal medicine
medicine
Animals
Prenatal Nutritional Physiological Phenomena
Mice, Inbred BALB C
Fetus
Fetal Growth Retardation
Nutrition and Dietetics
Ethanol
business.industry
Gene Expression Profiling
Brain
food and beverages
Prenatal Care
medicine.disease
Endocrinology
medicine.anatomical_structure
chemistry
Biochemistry
Fetal Alcohol Spectrum Disorders
Prenatal Exposure Delayed Effects
Microcephaly
Gestation
Female
business
Subjects
Details
- ISSN :
- 14752662 and 00071145
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- British Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....017a633a37a850671115c0054efff8f9