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A perspective profile of ADCY1 in cAMP signaling with drug-resistance in lung cancer
- Source :
- Journal of Cancer
- Publication Year :
- 2019
- Publisher :
- Ivyspring International Publisher, 2019.
-
Abstract
- Adenylate cyclase 1 (ADCY1 or AC1) is a member of ADCY superfamily and was primarily found to be expressed in the brain. ADCY1 is responsible for catalyzing ATP to cyclic AMP (cAMP). As a secondary messenger, cAMP can regulate plenty of cellular activities. cAMP can perform its regulation in cellular transport through the binding to cAMP dependent protein kinases (PKAs), cAMP-activated guanine exchange factors (EPACs) and cyclic nucleotide-gated channels functioning in transduction of sensory signals (CNGs). Lung cancer is one of the leading factors of cancer-related death worldwide. Platinum-based chemotherapy is the first-line treatment for advanced lung cancer patients. In addition, surgical treatment, radiation treatment, and molecular targeted therapy are also therapeutic options for lung cancer patients in clinical settings. However, drug resistance and toxicity are the major obstacles that affect chemotherapy outcome and prognosis of lung cancer patients. And the therapeutic efficiency and adverse effects are varying with each individual. In recent years, investigations based on genetic sequencing have revealed the emerging role of ADCY1 mutations in affecting drug efficiency in various cancers such as lung cancer, esophageal cancer and colorectal cancer. The potential function of ADCY1 in chemotherapy resistance is of great importance to be noticed and investigated.
- Subjects :
- 0301 basic medicine
Colorectal cancer
medicine.medical_treatment
Review
Drug resistance
Targeted therapy
03 medical and health sciences
0302 clinical medicine
cAMP
Medicine
Adverse effect
Lung cancer
Signaling pathway
business.industry
Kinase
Esophageal cancer
medicine.disease
ADCY1
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Cancer research
Signal transduction
business
Subjects
Details
- ISSN :
- 18379664
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Cancer
- Accession number :
- edsair.doi.dedup.....01c39cdbb3b80f2adf48ed8e4e8fb744