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Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
- Source :
- Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, Science (New York, N.Y.), Science (New York, N.Y.), vol 359, iss 6372
- Publication Year :
- 2018
-
Abstract
- Dissecting Plasmodium drug resistance Malaria is a deadly disease with no effective vaccine. Physicians thus depend on antimalarial drugs to save lives, but such compounds are often rendered ineffective when parasites evolve resistance. Cowell et al. systematically studied patterns of Plasmodium falciparum genome evolution by analyzing the sequences of clones that were resistant to diverse antimalarial compounds across the P. falciparum life cycle (see the Perspective by Carlton). The findings identify hitherto unrecognized drug targets and drug-resistance genes, as well as additional alleles in known drug-resistance genes. Science , this issue p. 191 ; see also p. 159
- Subjects :
- 0301 basic medicine
Nonsynonymous substitution
Genes, Protozoan
Druggability
Drug Resistance
Genome
Activation, Metabolic
chemistry.chemical_compound
2.2 Factors relating to the physical environment
Aetiology
Multidisciplinary
Drug discovery
Drug Resistance, Multiple
3. Good health
Infectious Diseases
Protozoan
Infection
Multiple
DNA Copy Number Variations
General Science & Technology
Plasmodium falciparum
Activation
Computational biology
Biology
Article
Vaccine Related
03 medical and health sciences
Antimalarials
Rare Diseases
Genetic
Biodefense
Genetics
Chemogenomics
Metabolomics
Selection, Genetic
Selection
Gene
Alleles
Prevention
Human Genome
biology.organism_classification
Malaria
Resistome
Vector-Borne Diseases
Emerging Infectious Diseases
Orphan Drug
Good Health and Well Being
030104 developmental biology
Genes
chemistry
Mutation
Metabolic
Antimicrobial Resistance
Directed Molecular Evolution
Genome, Protozoan
Transcription Factors
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, Science (New York, N.Y.), Science (New York, N.Y.), vol 359, iss 6372
- Accession number :
- edsair.doi.dedup.....01e8cf3f4266035d283abb3c97fc622b