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Early detection of memory deficits and memory improvement with vaccinia virus complement control protein in an Alzheimer's disease model
- Source :
- Behavioural Brain Research. 192:173-177
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Vaccinia virus complement control protein (VCP) inhibits both the classical and alternate complement pathways. In diseases such as traumatic brain injury (TBI) and Alzheimer's disease (AD), pathological inflammation is caused by amongst several factors, prolonged or inappropriate activation of the complement system and is a significant cause of neurodegeneration. This study investigates for the first time the use of a cheeseboard maze to evaluate cognitive deficits and the effect of VCP on memory processes in 2- and 3-month-old mice that express mutant amyloid precursor protein (APPswe) and mutant presenilin 1 (Ps1dE9) that correspond to a form of early onset AD. A four-phase training schedule was carried out on the cheeseboard maze before intracranial injections of 5 microl of VCP (1.7 microg/microl) or 5 microl saline. Two weeks later the effect of VCP on memory was evaluated. A statistically significant decrease in goal latency in VCP-treated mice than saline-treated transgenic mice in both the first probe and reverse tasks was observed. Similarly, after a second intracranial VCP or saline injection performed 2 months later, the 6.5- and 7.5-month aged VCP-injected mice performed significantly better in goal latency in both second probe and reverse tasks than saline-treated mice. These data also demonstrated that the use of a dry maze is a sensitive technique for distinguishing cognitive measures between non-transgenic and APPswe/PS1De9 transgenic mice at a much earlier stage.
- Subjects :
- Time Factors
Microinjections
Spatial Behavior
Mice, Transgenic
Presenilin
Amyloid beta-Protein Precursor
Mice
Viral Proteins
Behavioral Neuroscience
Alzheimer Disease
Memory
Memory improvement
Presenilin-1
medicine
Amyloid precursor protein
Animals
Memory disorder
Maze Learning
Analysis of Variance
Memory Disorders
Behavior, Animal
biology
Neurodegeneration
medicine.disease
Complement system
Disease Models, Animal
Early Diagnosis
Treatment Outcome
Mutation
Immunology
Exploratory Behavior
biology.protein
Alzheimer's disease
Psychology
Complement control protein
Subjects
Details
- ISSN :
- 01664328
- Volume :
- 192
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research
- Accession number :
- edsair.doi.dedup.....01ebcaf0b8bcd73f5a58a93c98a7ffa8