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In Vitro Study on Green Propolis as a Potential Ingredient of Oral Health Care Products

Authors :
Coluccia, Achille
Matti, Fabienne
Zhu, Xilei
Lussi, Adrian
Stähli, Alexandra
Sculean, Anton
Eick, Sigrun
Source :
Antibiotics; Volume 11; Issue 12; Pages: 1764, Coluccia, Achille; Matti, Fabienne; Zhu, Xilei; Lussi, Adrian; Stähli, Alexandra; Sculean, Anton; Eick, Sigrun (2022). In Vitro Study on Green Propolis as a Potential Ingredient of Oral Health Care Products. Antibiotics, 11(12) MDPI 10.3390/antibiotics11121764
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Propolis is increasingly being discussed as an alternative to commonly used antiseptics. This in vitro study focused on the ethanolic extract of green Brazilian propolis (EEPg) as an additive in an oral health care product. We investigated (i) a potential inflammation-modulation activity of EEPg when a periodontal or Candida biofilm was exposed to monocytic (MONO-MAC-6) cells, (ii) the adhesion of oral pathogens to gingival keratinocytes and (iii) the antimicrobial and antibiofilm effect of different toothpaste formulations. EEPg decreased the levels of interleukin (IL)-1β and increased IL-10 in MONO-MAC cells challenged with a periodontal biofilm. In contact with TIGK cells, EEPg reduced the numbers of adherent Porphyromonas gingivalis to 0.5% but did not affect the adhesion of Candida albicans. The frequent brushing of a cariogenic biofilm with a toothpaste supplemented with EEPg reduced the surface microhardness loss of enamel specimens. Mixing an experimental erythritol toothpaste with 25 and 50 mg/mL of EEPg confirmed the antibacterial activity of EEPg against oral bacteria and particularly inhibited periodontal biofilm formation. The suggested toothpaste formulations seem to have potential in the prevention of caries, gingivitis and periodontitis and should be evaluated in further in vitro research and in clinical trials.

Details

ISSN :
20796382
Volume :
11
Database :
OpenAIRE
Journal :
Antibiotics
Accession number :
edsair.doi.dedup.....020b1bd66c7789f199d39eee69d14a31
Full Text :
https://doi.org/10.3390/antibiotics11121764