Back to Search
Start Over
Clinical course, severity and mortality in a cohort of patients with COVID-19 with rheumatic diseases
- Source :
- Annals of the Rheumatic Diseases
- Publication Year :
- 2020
- Publisher :
- BMJ, 2020.
-
Abstract
- The recent outbreak caused by a novel severe acute respiratory syndrome coronavirus 2 disease 2019 (COVID-19) has spread rapidly worldwide, and it has been declared a pandemic by the WHO.1 Elder people, male sex and some underlying comorbidities seem to be risk factors for morbidity and mortality, although an immunosuppressive status could favour the infection and the development of complications.2 However, as progress is made in the knowledge of the physiopathology of COVID-19, it has been observed that severe respiratory forms occur as a result of an hyperinflammatory status and an excessive production of cytokines.3 In this descriptive retrospective study, we aimed to characterise features related to severity and mortality in these patients and the influence of immune modulating drugs on the course of the infection. Patients were included from 25 February 2020 to 8 June 2020 with COVID-19 infection and rheumatic inflammatory diseases from Rheumatology Department of La Paz University Hospital. One hundred and twenty-two patients were included. One hundred (82.0%) were confirmed through nasopharyngeal swabs. Twenty-two patients (18.0%) exhibited compatible symptoms with compatible lung imaging and/or positive serology. Patients characteristics are shown in …
- Subjects :
- Male
0301 basic medicine
Letter
Disease
Azithromycin
Severity of Illness Index
Lopinavir
Arthritis, Rheumatoid
Cohort Studies
0302 clinical medicine
Pandemic
Lupus Erythematosus, Systemic
Immunology and Allergy
Medicine
Respiratory system
Immunoglobulins, Intravenous
Middle Aged
Pathophysiology
Drug Combinations
biological therapy
Antirheumatic Agents
Cohort
Female
Coronavirus Infections
Hydroxychloroquine
Adult
medicine.medical_specialty
Pneumonia, Viral
Immunology
Antiviral Agents
General Biochemistry, Genetics and Molecular Biology
Betacoronavirus
03 medical and health sciences
Immune system
Rheumatology
Rheumatic Diseases
Internal medicine
Humans
Immunologic Factors
autoimmune diseases
Glucocorticoids
Pandemics
Aged
Retrospective Studies
030203 arthritis & rheumatology
Ritonavir
SARS-CoV-2
business.industry
Arthritis, Psoriatic
COVID-19
Outbreak
Retrospective cohort study
COVID-19 Drug Treatment
030104 developmental biology
Spondylarthropathies
business
Subjects
Details
- ISSN :
- 14682060 and 00034967
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- Annals of the Rheumatic Diseases
- Accession number :
- edsair.doi.dedup.....02145e6b43e395b9477311a1e7074177