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Hypothyroidism attenuates SCH 23390-mediated depression of breathing and decreases d1 receptor expression in carotid bodies, PVN and striatum of hamsters
- Source :
- Brain Research. 1401:40-51
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Hypothyroidism can lead to depressed breathing. We determined if propylthiouracil (PTU)-induced hypothyroidismin hamsters (HH) altered dopamine D1 receptor expression, D1 receptor-modulated ventilation, and ventilatory chemoreflex activation by hypoxia or hypercapnia. Hypothyroidism was induced by administering 0.04% PTU in drinking water for 3 months. Ventilation was evaluated following saline or 0.25mg/kg SCH 23390,a D1 receptor antagonist, while awake hamsters breathed normoxic (21% O(2) in N(2)), hypoxic (10% O(2)in N(2)) and hypercapnic (5% CO(2) in O(2))air. Relative to euthyroid hamsters (EH), HH exhibited decreased D1 receptor protein levels in carotid bodies, striatum, and hypothalamic paraventricular nucleus, but not in the nucleus tractus solitarius. Relative to EH, HH exhibited lower ventilation during exposure to normoxia, hypoxia, or hypercapnia, but comparable ventilatory responsiveness to chemoreflex activation. SCH23390 decreased ventilation of EH hamsters exposed to normoxia, hypoxia, and hypercapnia. In HH SCH23390 increased ventilation during baseline normoxia and did not affect ventilation during exposure to hypoxia and hypercapnia, resulting in reduced ventilatory responsivess to chemoreflex activation by hypoxia and hypercapnia. Furthermore, in HH D1 receptor protein levels are decreased in several brain regions and within the carotid bodies. Moreover, D1 receptor-modulation of breathing at rest and during gas exposures were depressed in EH but not HH.
- Subjects :
- Male
medicine.medical_specialty
Chemoreceptor
Down-Regulation
Striatum
Article
chemistry.chemical_compound
Dopamine receptor D1
Hypothyroidism
Dopamine
Cricetinae
Internal medicine
medicine
Animals
Molecular Biology
Carotid Body
SCH-23390
Mesocricetus
business.industry
Receptors, Dopamine D1
Respiration
General Neuroscience
Benzazepines
Hypoxia (medical)
Corpus Striatum
medicine.anatomical_structure
Endocrinology
chemistry
Respiratory Mechanics
Carotid body
Neurology (clinical)
medicine.symptom
Respiratory Insufficiency
business
Hypercapnia
hormones, hormone substitutes, and hormone antagonists
Paraventricular Hypothalamic Nucleus
circulatory and respiratory physiology
Developmental Biology
medicine.drug
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 1401
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....021e359a31eeb1864a07c1d94fbf790f