Back to Search
Start Over
Multivariate Meta-Analysis of Preference-Based Quality of Life Values in Coronary Heart Disease
Multivariate Meta-Analysis of Preference-Based Quality of Life Values in Coronary Heart Disease
- Source :
- PLoS ONE, PLoS ONE, 11(3):e0152030. PUBLIC LIBRARY SCIENCE, PLoS ONE, Vol 11, Iss 3, p e0152030 (2016)
- Publication Year :
- 2016
- Publisher :
- PUBLIC LIBRARY SCIENCE, 2016.
-
Abstract
- BackgroundThere are numerous health-related quality of life (HRQol) measurements used in coronary heart disease (CHD) in the literature. However, only values assessed with preference-based instruments can be directly applied in a cost-utility analysis (CUA).ObjectiveTo summarize and synthesize instrument-specific preference-based values in CHD and the underlying disease-subgroups, stable angina and post-acute coronary syndrome (post-ACS), for developed countries, while accounting for study-level characteristics, and within- and between-study correlation.MethodsA systematic review was conducted to identify studies reporting preference-based values in CHD. A multivariate meta-analysis was applied to synthesize the HRQoL values. Meta-regression analyses examined the effect of study level covariates age, publication year, prevalence of diabetes and gender.ResultsA total of 40 studies providing preference-based values were detected. Synthesized estimates of HRQoL in post-ACS ranged from 0.64 (Quality of Well-Being) to 0.92 (EuroQol European"tariff"), while in stable angina they ranged from 0.64 (Short form 6D) to 0.89 (Standard Gamble). Similar findings were observed in estimates applying to general CHD. No significant improvement in model fit was found after adjusting for study-level covariates. Large between-study heterogeneity was observed in all the models investigated.ConclusionsThe main finding of our study is the presence of large heterogeneity both within and between instrument-specific HRQoL values. Current economic models in CHD ignore this between-study heterogeneity. Multivariate meta-analysis can quantify this heterogeneity and offers the means for uncertainty around HRQoL values to be translated to uncertainty in CUAs.
- Subjects :
- Male
Multivariate statistics
Multivariate analysis
Cost effectiveness
Cardiovascular Procedures
STANDARD GAMBLE
Cost-Benefit Analysis
Myocardial Infarction
lcsh:Medicine
Coronary Disease
Time-trade-off
Vascular Medicine
Choice Behavior
COST-EFFECTIVENESS
0302 clinical medicine
Mathematical and Statistical Techniques
Endocrinology
Quality of life
Surveys and Questionnaires
Medicine and Health Sciences
TIME TRADE-OFF
Medicine
Coronary Heart Disease
030212 general & internal medicine
lcsh:Science
OUTCOMES
Multidisciplinary
Coronary Artery Bypass Grafting
HEALTH UTILITIES INDEX
030503 health policy & services
Patient Preference
Angina
Middle Aged
Models, Economic
Meta-analysis
Physical Sciences
Regression Analysis
Female
0305 other medical science
INTERVENTION
Statistics (Mathematics)
Health Utilities Index
Research Article
medicine.medical_specialty
Patients
Psychometrics
Endocrine Disorders
Cardiology
UNITED-STATES
Surgical and Invasive Medical Procedures
Research and Analysis Methods
Angina Pectoris
03 medical and health sciences
EQ-5D
Diabetes Mellitus
Humans
Statistical Methods
Acute Coronary Syndrome
Aged
business.industry
lcsh:R
ELEVATION MYOCARDIAL-INFARCTION
Surgery
Health Care
Metabolic Disorders
Multivariate Analysis
Quality of Life
lcsh:Q
business
FOLLOW-UP
Mathematics
Demography
Meta-Analysis
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PLOS-One
- Accession number :
- edsair.doi.dedup.....02235802212a5294ff22cac0bae6527f
- Full Text :
- https://doi.org/10.1371/journal.pone.0152030