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Enantioselective Construction of Axially Chiral Azepine-Containing P,N-Ligands from <scp>l</scp>-Alanine
- Source :
- Organic Letters. 23:7814-7818
- Publication Year :
- 2021
- Publisher :
- American Chemical Society (ACS), 2021.
-
Abstract
- A family of axially chiral azepine-containing seven-membered cyclic P,N-ligands (named Indole-azepinap) have been prepared by using l-alanine as an original chirality source. The direct chromatographic separation of two diastereomeric phosphine oxides on silica gel enabled these ligands to be easy available, allowing further structural and electronic modifications. Preliminary application of these Indole-azepinaps has been demonstrated in a Pd-catalyzed asymmetric allylic alkylation with high yields and moderate enantioselectivities.
- Subjects :
- Alanine
Indoles
Alkylation
Molecular Structure
Phosphines
Chemistry
Silica gel
organic chemicals
Organic Chemistry
Diastereomer
Enantioselective synthesis
Stereoisomerism
Azepines
Ligands
Biochemistry
Combinatorial chemistry
Catalysis
Tsuji–Trost reaction
chemistry.chemical_compound
Physical and Theoretical Chemistry
Azepine
Chirality (chemistry)
Palladium
Phosphine
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....022a3f1cfd9043e9797564e1e881dea1