Serotonin-Induced Muscle Weakness

Authors :: W. King Engel
Bernard M. Patten
Katharine L. Oliver
Source :: Archives of Neurology. 31:347-349
Publication Year :: 1974
Publisher :: American Medical Association (AMA), 1974.
Abstract: Infusions of serotonin into a rat nervemuscle preparation decreased the force of the evoked twitch of anterior tibial and soleus muscles. Antiserotonin drugs (cyproheptadine hydrochloride, methysergide, chlorpromazine hydrochloride) prevented the adverse effect of serotonin if they were given prior to the serotonin infusion. These experiments support the hypothesis that serotonin may play a role in some diseases of muscle.

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