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Epithelial-mesenchymal transition as strategic microenvironment mimicry for cancer cell survival and immune escape?
- Source :
- Genes and Diseases, Vol 4, Iss 1, Pp 16-18 (2017)
- Publisher :
- Chongqing Medical University. Production and hosting by Elsevier B.V.
-
Abstract
- Epithelial-mesenchymal transition (EMT) is the phenotypic transition of epithelial cells to mesenchymal cells characterized by loss of epithelial markers, loss of intercellular adherence and acquirement of mesenchymal cell markers and increased locomotive ability. EMT is widely considered to be a gene regulated process necessary for cancer metastasis. Yet it is a highly controversial issue. We here propose that EMT is an environmentally induced cell behavior. It is the mimicry of their living environment. It is a survival strategy, a way of immune escape. We also propose here that the epithelial cell markers may functionally act as tumor antigens since in the mesenchymal surroundings there are no other structures bearing the same antigens as epithelial cells.
- Subjects :
- 0301 basic medicine
lcsh:QH426-470
Cell
Biology
Biochemistry
03 medical and health sciences
0302 clinical medicine
Antigen
medicine
Mimicry
Epithelial–mesenchymal transition
Molecular Biology
Genetics (clinical)
Cancer
lcsh:R5-920
Immune escape
Mesenchymal stem cell
EMT
Cell Biology
medicine.disease
Phenotype
Epithelium
lcsh:Genetics
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Immunology
Cancer cell
Cancer research
lcsh:Medicine (General)
Subjects
Details
- Language :
- English
- ISSN :
- 23523042
- Database :
- OpenAIRE
- Journal :
- Genes & Diseases
- Accession number :
- edsair.doi.dedup.....0230a9dcde11fdcf97cc7f11231dd5f7
- Full Text :
- https://doi.org/10.1016/j.gendis.2016.10.001