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Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial
Authors :
Hochman, JS Reynolds, HR Bangalore, S O'Brien, SM Alexander, KP Senior, R Boden, WE Stone, GW Goodman, SG Lopes, RD Lopez-Sendon, J White, HD Maggioni, AP Shaw, LJ Min, JK Picard, MH Berman, DS Chaitman, BR Mark, DB Spertus, JA Cyr, DD Bhargava, B Ruzyllo, W Wander, GS Chernyavskiy, AM Rosenberg, YD Maron, DJ Mavromatis, K Miller, T Banerjee, S Abdul-Nour, K Stone, PH Jang, JJ Weitz, S Arnold, S Shapiro, MD El-Hajjar, M McFalls, EO Khouri, MG Goldberg, JL Goldweit, R Cohen, RA Winchester, DE Kronenberg, M Heitner, JF Dauber, IM Cannan, C Sudarshan, S Mehta, PK Hedgepeth, CM Sahul, Z Booth, D Setty, S Barua, RS Hage, F Dajani, K Arif, I Trejo (Gutierrez), JF Gemignani, A Meadows, JL Call, JT Hannan, J Martin, ET Vorobiof, G Moorman, A Kinlay, S Rayos, G Seedhom, A Kumkumian, G Sedlis, SP Tamis-Holland, JE Saba, S Badami, U Marzo, K Robbins, IH Hamroff, GS Little, RW Lui, CY Hu, B Labovitz, AJ Rodriguez, F Deedwania, P Sweeny, J Spizzieri, C Hochberg, CP Salerno, WD Wyman, R Zarka, A Haldis, T Kohn, JA Girotra, S Almousalli, O Krishnam, MS Coram, R Thomas, S El Shahawy, M Stafford, J Abernethy, WB Zurick, A Meyer, TM Rutkin, B Bokhari, S Sokol, SI Hamzeh, I Turner, MC Good, AP Shammas, NW Chilton, R Nguyen, PK Jezior, M Gordon, PC Stenberg, R Pedalino, RP Wiesel, J Juang, GJ Al-Amoodi, M Wohns, D Lader, EW Mumma, M Dharmarajan, L McGarvey, JFX Downes, TR Cheong, B Potluri, S Mastouri, RA Li, D Giedd, K Old, W Burt, F Sokhon, K Gopal, D Valeti, US Kobashigawa, J Govindan, SC Manjunath, CN Pandit, N Dwivedi, SK Mathew, A Gadkari, MA Satheesh, S Mathur, A Christopher, J Oomman, A Naik, S Grant, P Kachru, R Kumar, A Kaul, U Gamma, RA De Belder, MA Nageh, T Lindsay, SJ Hoye, A Donnelly, P Chauhan, A Barr, C Alfakih, K Henriksen, P Okane, P De Silva, R Conway, DSG Sirker, AA Hoole, SP Witherow, FN Johnston, N Luckie, M Sobolewska, J Jeetley, P Travill, C Braganza, D Henderson, R Berry, C Moriarty, AJ Glover, JD Mikhail, G Gosselin, G Diaz, A Phaneuf, DC Garg, P Chow, BJW Bainey, KR Cheema, AN Cha, J Howarth, AG Wong, G Uxa, A Galiwango, P Lam, A Mehta, S Udell, J Genereux, P Hameed, A Daba, L Hueb, W Smanio, PEP De Quadros, AS Vitola, JV Marin-Neto, JA Polanczyk, CA Carvalho, AC Alves Junior, AR Dracoulakis, MDA Figueiredo, E Caramori, PR Tumelero, R Dall'Orto, F Mesquita, CT Ribeiro da Silva, EE Saraiva, JF Costantini, C Demkow, M Mazurek, T Drozdz, J Szwed, H Witkowski, A Gajos, G Pruszczyk, P Loboz-Grudzien, K Lesiak, M Reczuch, KW Kalarus, Z Musial, WJ Bockeria, L Bershtein, LL Demchenko, EA Lopez-Sendon, JL Peteiro, J Gonzalez Juanatey, JR Sionis, A Miro, V Ortuno, FM Blancas, MG Luena, JEC Fernandez-Aviles, F Chen, J Wu, Y Ma, Y Ji, Z Yang, X Lin, W Zeng, H Fu, X Yang, B Wang, S Cheng, G Zhao, Y Fang, X Zeng, Q Su, X Li, Q Nie, S-P Yu, Q Wang, J Zhang, S Perna, GP Provasoli, S Monti, L Di Chiara, A Mortara, A Galvani, M Sicuro, M Calabro, P Tarantini, G Racca, E Briguori, C Amati, R Russo, A Poh, K-K Foo, D Chua, T Doerr, R Sechtem, U Schulze, PC Nickenig, G Schuchlenz, H Lang, IM Huber, K Vertes, A Varga, A Fontos, G Merkely, B Kerecsen, G Hinic, S Beleslin, BD Cemerlic-Adjic, N Davidovic, G Dekleva, MN Stankovic, G Apostolovic, S Escobedo, J Rosas, EA Selvanayagam, JB Thambar, ST Beltrame, JF Hillis, GS Thuaire, C Steg, P-G Slama, MS El Mahmoud, R Nicollet, E Barone-Rochette, G Furber, A Laucevicius, A Kedhi, E Riezebos, RK Suryapranata, H Ramos, R Pinto, FJ Ferreira, N Guzman, L Figal, JC Alvarez, C Courtis, J Schiavi, L Rubio, M Devlin, GP Stewart, RAH Kedev, S Held, C Aspberg, J Sharir, T Kerner, A Fukuda, K Yasuda, S Nishimura, S Goetschalckx, K Hung, C-L Ntsekhe, M Moccetti, T Abdelhamid, M Pop, C Popescu, BA Al-Mallah, MH Ramos, WEM Kuanprasert, S Yamwong, S Khairuddin, A Ferguson, B Harrington, R Williams, D Berger, J Newman, J Sidhu, M Dzavik, V Jiang, L Keltai, M Kohsaka, S Maggioni, A Mancini, GBJ Merz, CNB Weintraub, W Ballantyne, C Calfas, KJ Davidson, M Friedrich, M Hachamovitch, R Kwong, R Harrell, F Kullo, I McManus, B Cohen, DJ Bugiardini, R Celutkiene, J Lyubarova, R Mattina, D Nwosu, S Broderick, S Cyr, D Rockhold, F Anstrom, K Jones, P Phillips, L Hayes, SW Friedman, JD Gerlach, RJ Kwong, RY Mongeon, FP Hung, J Scherrer-Crosbie, M Zeng, X Ali, Z Arsanjani, R Budoff, M Leipsic, J Nakanishi, R Youn, T Orso, F Zhang, H Zhang, L Diaz, R Van de Werf, F Fleg, J Kirby, R Jeffries, N Hochman JS, Reynolds HR, Bangalore S, O'Brien SM, Alexander KP, Senior R, Boden WE, Stone GW, Goodman SG, Lopes RD, Lopez-Sendon J, White HD, Maggioni AP, Shaw LJ, Min JK, Picard MH, Berman DS, Chaitman BR, Mark DB, Spertus JA, Cyr DD, Bhargava B, Ruzyllo W, Wander GS, Chernyavskiy AM, Rosenberg YD, Maron DJ, Mavromatis K, Miller T, Banerjee S, Abdul-Nour K, Stone PH, Jang JJ, Weitz S, Arnold S, Shapiro MD, El-Hajjar M, McFalls EO, Khouri MG, Goldberg JL, Goldweit R, Cohen RA, Winchester DE, Kronenberg M, Heitner JF, Dauber IM, Cannan C, Sudarshan S, Mehta PK, Hedgepeth CM, Sahul Z, Booth D, Setty S, Barua RS, Hage F, Dajani K, El-Hajjar M, Arif I, Trejo JF, Gemignani A, Meadows JL, Call JT, Hannan J, Martin ET, Vorobiof G, Moorman A, Kinlay S, Rayos G, Seedhom A, Kumkumian G, Sedlis SP, Tamis-Holland JE, Saba S, Badami U, Marzo K, Robbins IH, Hamroff GS, Little RW, Lui CY, Booth D, Hu B, Labovitz AJ, Maron DJ, Rodriguez F, Deedwania P, Sweeny J, Spizzieri C, Hochberg CP, Salerno WD, Wyman R, Zarka A, Haldis T, Kohn JA, Girotra S, Almousalli O, Krishnam MS, Coram R, Thomas S, El Shahawy M, Stafford J, Abernethy WB, Zurick A, Meyer TM, Rutkin B, Bokhari S, Sokol SI, Hamzeh I, Turner MC, Good AP, Shammas NW, Chilton R, Nguyen PK, Jezior M, Gordon PC, Stenberg R, Pedalino RP, Wiesel J, Juang GJ, Al-Amoodi M, Wohns D, Lader EW, Mumma M, Dharmarajan L, McGarvey JFX, Downes TR, Cheong B, Potluri S, Mastouri RA, Li DY, Giedd K, Old W, Burt F, Sokhon K, Gopal D, Valeti US, Kobashigawa J, Govindan SC, Manjunath CN, Pandit N, Dwivedi SK, Wander G, Bhargava B, Mathew A, Gadkari MA, Satheesh S, Mathur A, Christopher J, Oomman A, Naik S, Christopher J, Grant P, Kachru R, Kumar A, Christopher J, Kaul U, Gamma RA, de Belder MA, Nageh T, Lindsay SJ, Hoye A, Donnelly P, Chauhan A Barr C, Alfakih K, Henriksen P, Okane P, de Silva R, Conway DSG, Sirker AA, Hoole SP, Witherow FN, Johnston N, Luckie M, Sobolewska J, Jeetley P, Travill C, Braganza D, Henderson R, Berry C, Moriarty AJ, Glover JD, Mikhail G, Gosselin G, Diaz A, Phaneuf DC, Garg P, Chow BJW, Bainey KR, Cheema AN, Cheema AN, Cha J, Howarth AG, Wong G, Uxa A, Galiwango P, Lam A, Mehta S, Udell J, Genereux P, Hameed A, Daba L, Hueb W, Smanio PEP, de Quadros AS, Vitola JV, Marin-Neto JA, Polanczyk CA, Carvalho AC, Alves AR, Dracoulakis MDA, Figueiredo E, Caramori PR, Tumelero R, Dall'Orto F, Mesquita CT, da Silva EER, Saraiva JF, Costantini C, Demkow M, Mazurek T, Drozdz J, Szwed H, Witkowski A, Gajos G, Pruszczyk P, Loboz-Grudzien K, Lesiak M, Reczuch KW, Kalarus Z, Musial WJ, Bockeria L, Chernyavskiy AM, Bershtein LL, Demchenko EA, Lopez-Sendon JL, Peteiro J, Juanatey JRG, Sionis A, Miro V, Ortuno FM, Blancas MG, Luena JEC, Fernandez-Aviles F, Chen JY, Wu YJ, Ma YT, Ji Z, Yang XC, Lin WH, Zeng HS, Fu, X, Yang B, Wang ST, Cheng G, Zhao YL, Fang XH, Zeng QT, Su X, Li QX, Nie SP, Yu Q, Wang JA, Zhang SY, Perna GP, Provasoli S, Monti L, Di Chiara A, Mortara A, Galvani M, Sicuro M, Calabro P, Tarantini G, Racca E , Briguori C, Amati R, Russo A, Poh KK, Foo D, Chua, Doerr R, Sechtem U, Schulze PC, Nickenig G, Schuchlenz H, Lang IM, Huber K, Vertes A, Varga A, Fontos G, Merkely B, Kerecsen G, Hinic S, Beleslin BD, Cemerlic-Adjic N, Davidovic G, Dekleva MN, Stankovic G, Apostolovic S, Escobedo J, Rosas EA, Selvanayagam JB, Thambar ST, Beltrame JF, Hillis GS, Thuaire C, Steg PG, Slama MS, El Mahmoud R, Nicollet E, Barone-Rochette G, Furber A, Laucevicius A, Kedhi E, Riezebos RK, Suryapranata H, Ramos R, Pinto FJ, Ferreira N, Guzman L, Figal JC, Alvarez C, Courtis J, Schiavi L, Rubio M, Devlin GP, Stewart RAH, Kedev S, Held C, Aspberg, J, Sharir T, Kerner A, Fukuda K, Yasuda S, Nishimura S , Goetschalckx K, Hung CL, Ntsekhe M, Moccetti T, Abdelhamid M, Pop C, Popescu BA, Al-Mallah MH, Ramos WEM, Kuanprasert S, Yamwong S, Khairuddin A, O'Brien SM, Boden WE, Ferguson B, Harrington R, Stone GW, Williams D, Berger J, Newman J, Sidhu M, Mark DB, Shaw LJ, Spertus JA, Berman DS, Chaitman BR, Doerr R, Dzavik V, Goodman SG, Gosselin G, Held C, Jiang LX, Keltai M, Kohsaka S, Lopes RD, Lopez-Sendon JL, Maggioni A, Mancini GBJ, Merz CNB, Min JK, Picard MH, Ruzyllo W, Selvanayagam JB, Senior R, Steg PG, Szwed H, Weintraub W, White HD, Ballantyne C, Calfas KJ, Davidson M, Stone PH, Friedrich M, Hachamovitch R, Kwong R, Harrell F, Kullo I, McManus B, Cohen DJ, Bugiardini R, Celutkiene J, Escobedo J , Hoye A, Lyubarova R, Mattina D, Peteiro J, Nwosu S, Broderick S, Cyr D, Rockhold F, Anstrom K, Jones P, Phillips L, Hayes SW, Friedman JD, Gerlach RJ, Kwong RY, Mongeon FP, Hung J, Scherrer-Crosbie M, Zeng X, Ali Z, Genereux P, Arsanjani R, Budoff M, Leipsic J, Nakanishi R, Youn T , Orso F, Carvalho AC, Zhang HB, Zhang LH, Diaz R, Van de Werf F, Goetschalckx K, Rosenberg YD, Fleg J, Kirby R, Jeffries N.
Source :
JAMA Cardiology, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname
Publication Year :
2019
Publisher :
AMER MEDICAL ASSOC, 2019.
Abstract
Importance It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. Objective To describe baseline characteristics of participants enrolled and randomized in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial and to evaluate whether qualification by stress imaging or nonimaging exercise tolerance test (ETT) influenced risk profiles. Design, Setting, and Participants The ISCHEMIA trial recruited patients with SIHD with moderate or severe ischemia on stress testing. Blinded coronary computed tomography angiography was performed in most participants and reviewed by a core laboratory to exclude left main stenosis of at least 50% or no obstructive coronary artery disease (CAD) (
Details
ISSN :
23806583
Database :
OpenAIRE
Journal :
JAMA Cardiology, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname
Accession number :
edsair.doi.dedup.....023807fe7b838400d13eb0b6a56bea4a