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Synthesis, characterization and potent superoxide dismutase like activity of novel bis(pyrazole) – 2,2′-bipyridyl mixed ligand copper(II) complexes
- Publication Year :
- 2009
-
Abstract
- Eleven new complexes of Cu(II) chloride and nitrate with bis(pyrazol-1-yl)propane and bis[2-(pyrazol-1-yl)ethyl]ether ligands were prepared and characterized by spectral and electrochemical methods. X-Ray crystal structure determination of bis[2-(3,5-dimethylpyrazol-1-yl)ethyl]etherdinitratocopper revealed a hepta-coordinated structure with the bis(pyrazole) ligand coordinated in a tridentate NNO-fashion and both of the nitrate ions in a bidentate fashion. Reaction of Cu(II) nitrate complexes with 2,2'-bipyridyl led to the displacement of one of the nitrate ions into the outer sphere and the formation of mixed-ligand complexes. Mixed-ligand bipyridyl Cu(II) complexes demonstrated the highest superoxide dismutase (SOD)-like activity in a chemical superoxide anion-generating system, with IC(50) values in the low micromolar range. Density functional theory calculations showed that introduction of a bipypidyl ligand into the complexes dramatically lowered the lowest unoccupied molecular orbital (LUMO) energy level, which explains the increased SOD-like activity of these complexes compared to non-bipy species. These bipy complexes were also effective scavengers of reactive oxygen species generated by phagocytes (human neutrophils and murine bone marrow leukocytes) ex vivo. Thus, these bipy mixed-ligand complexes represent a promising class of SOD mimetics for future development.
- Subjects :
- Models, Molecular
Denticity
Stereochemistry
Cell Survival
Molecular Conformation
Ether
Electrons
Pyrazole
Crystallography, X-Ray
Ligands
Medicinal chemistry
Article
Cell Line
Inorganic Chemistry
Superoxide dismutase
chemistry.chemical_compound
Mice
2,2'-Dipyridyl
Biomimetic Materials
Electrochemistry
Organometallic Compounds
Animals
Humans
HOMO/LUMO
Cell Proliferation
chemistry.chemical_classification
Reactive oxygen species
biology
Ligand
Superoxide
Superoxide Dismutase
Spectrum Analysis
Free Radical Scavengers
chemistry
biology.protein
Quantum Theory
Cattle
Copper
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....02530bb508f1a1985dabd9cc3bf3dbdb