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Muscle‐bone crosstalk and potential therapies for sarco‐osteoporosis
- Source :
- J Cell Biochem
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- The nature of muscle-bone crosstalk has been historically considered to be only mechanical, where the muscle is the load applier while bone provides the attachment sites. However, this dogma has been challenged with the emerging notion that bone and muscle act as secretory endocrine organs affect the function of each other. Biochemical crosstalk occurs through myokines such as myostatin, irisin, interleukin (IL)-6, IL-7, IL-15, insulin-like growth factor-1, fibroblast growth factor (FGF)-2, and β-aminoisobutyric acid and through bone-derived factors including FGF23, prostaglandin E(2), transforming growth factor β, osteocalcin, and sclerostin. Aside from the biochemical and mechanical interaction, additional factors including aging, circadian rhythm, nervous system network, nutrition intake, and exosomes also have effects on bone-muscle crosstalk. Here, we summarize the current research progress in the area, which may be conductive to identify potential novel therapies for the osteoporosis and sarcopenia, especially when they develop in parallel.
- Subjects :
- 0301 basic medicine
Aging
Osteocalcin
Osteoporosis
Muscle Proteins
Myostatin
Fibroblast growth factor
Bioinformatics
Biochemistry
Bone and Bones
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Myokine
medicine
Humans
Nervous System Physiological Phenomena
Muscle, Skeletal
Molecular Biology
biology
business.industry
Cell Biology
medicine.disease
Circadian Rhythm
Fibroblast Growth Factor-23
Crosstalk (biology)
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Sarcopenia
biology.protein
Sclerostin
business
Protein Binding
Signal Transduction
Transforming growth factor
Subjects
Details
- ISSN :
- 10974644 and 07302312
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Biochemistry
- Accession number :
- edsair.doi.dedup.....025fcbb1b23ae57289dba8b7af741ccf