Back to Search
Start Over
Tumor volume reduction rate is superior to RECIST for predicting the pathological response of rectal cancer treated with neoadjuvant chemoradiation: Results from a prospective study
- Source :
- Oncology Letters. 9:2680-2686
- Publication Year :
- 2015
- Publisher :
- Spandidos Publications, 2015.
-
Abstract
- The aim of the present study was to compare the tumor volume reduction rate (TVRR), as determined by three-dimensional region-of-interest magnetic resonance volumetry, and Response Evaluation Criteria in Solid Tumors (RECIST) data for predicting the pathological tumor response (PTR) of locally advanced rectal cancer (LARC) following treatment with neoadjuvant chemoradiation (CRT). The current cohort consisted of 105 patients with LARC [clinical tumor stage (cT)3–4 or clinical lymph node stage (cN)+] from a prospective randomized trial who had undergone pre-operative CRT and radical proctectomy. Tumor volumes were measured prior to and following CRT to determine TVRR. Furthermore, receiver operating characteristic (ROC) curves of TVRR and RECIST were constructed to predict the PTR in terms of tumor regression grade (TRG) and downstaging. Values for the area under the ROC curve (AUC) were compared and TVRR cut-off levels were determined. RECIST was used to identify 5 (4.8%) cases of complete response, 44 (41.9%) of partial response, 55 (52.4%) of stable disease and 1 (0.9%) of progressive disease. The mean TVRR was 58.6±24.4%, and a good TRG (0–1) and downstaging occurred in 54 (51.4%) and 59 (56.2%) patients, respectively. In addition, TVRR and RECIST were significantly correlated with TRG and downstaging (P
- Subjects :
- Tumor Regression Grade
Cancer Research
medicine.medical_specialty
Receiver operating characteristic
Colorectal cancer
business.industry
Articles
medicine.disease
Surgery
medicine.anatomical_structure
Oncology
Response Evaluation Criteria in Solid Tumors
medicine
Stage (cooking)
Nuclear medicine
business
Prospective cohort study
Lymph node
Progressive disease
Subjects
Details
- ISSN :
- 17921082 and 17921074
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Oncology Letters
- Accession number :
- edsair.doi.dedup.....02a6236f7b1c68aa4a801f37f8831df3