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Anaemia and physical and mental health in the very old: An individual participant data meta-analysis of four longitudinal studies of ageing
- Source :
- Age and Ageing, 50(1), 113-119. OXFORD UNIV PRESS
- Publication Year :
- 2021
- Publisher :
- OXFORD UNIV PRESS, 2021.
-
Abstract
- Objective To determine the physical and mental health of very old people (aged 80+) with anaemia. Methods Individual level meta-analysis from five cohorts of octogenarians (n = 2,392): LiLACS NZ Māori, LiLACS NZ non-Māori, Leiden 85-plus Study, Newcastle 85+ Study, and TOOTH. Mixed models of change in functional ability, cognitive function, depressive symptoms, and self-rated health over time were separately fitted for each cohort. We combined individual cohort estimates of differences according to the presence of anaemia at baseline, adjusting for age at entry, sex, and time elapsed. Combined estimates are presented as differences in standard deviation units (i.e. standardised mean differences–SMDs). Results The combined prevalence of anaemia was 30.2%. Throughout follow-up, participants with anaemia, on average, had: worse functional ability (SMD −0.42 of a standard deviation across cohorts; CI -0.59,-0.25); worse cognitive scores (SMD -0.27; CI -0.39,-0.15); worse depression scores (SMD -0.20; CI -0.31,-0.08); and lower ratings of their own health (SMD -0.36; CI -0.47,-0.25). Differential rates of change observed were: larger declines in functional ability for those with anaemia (SMD −0.12 over five years; CI -0.21,-0.03) and smaller mean difference in depression scores over time between those with and without anaemia (SMD 0.18 over five years; CI 0.05,0.30). Conclusion Anaemia in the very old is a common condition associated with worse functional ability, cognitive function, depressive symptoms, and self-rated health, and a more rapid decline in functional ability over time. The question remains as to whether anaemia itself contributes to worse outcomes or is simply a marker of chronic diseases and nutrient deficiencies.
- Subjects :
- Aging
Activities of daily living
Anemia
Anaemia
03 medical and health sciences
0302 clinical medicine
030502 gerontology
80 and over
Humans
Medicine
Longitudinal Studies
030212 general & internal medicine
Functional ability
Depression (differential diagnoses)
Aged
Aged, 80 and over
business.industry
Depression
Cognition
General Medicine
medicine.disease
Mental health
Mental Health
Meta-analysis
Cohort
Cognitive function
Geriatrics and Gerontology
0305 other medical science
business
Demography
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Age and Ageing, 50(1), 113-119. OXFORD UNIV PRESS
- Accession number :
- edsair.doi.dedup.....02bbe29f46031ede3eb63e7f417a0c34