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Global molecular alterations involving recurrence or progression of pediatric brain tumors
- Source :
- Neoplasia (New York, N.Y.), Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 1, Pp 22-33 (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Background: We aimed to identify molecular changes in recurrent or progressive pediatric brain tumors, as compared to the corresponding initial tumors from the same patients, using genomic, transcriptomic, and proteomic data from a unique and large cohort of 55 patients and 63 recurrent or progressive tumors from the Children's Brain Tumor Tissue Consortium, representing various histologic types. Methods: We carried out paired analyses for each gene between recurrent/progressive and initial tumor groups, using RNA-sequencing and mass spectrometry-based proteomic data. By whole-genome sequencing (WGS) analysis, we also examined somatic DNA events for a set of cancer-associated genes. Results: Of 44 patients examined by WGS, 35 involved at least one cancer-associated gene with a somatic alteration event in a recurrent or progressive tumor that was not present in the initial tumor, including genes NF1, CDKN2A, CCND2, EGFR, and MYCN. By paired analysis, 68 mRNA transcripts were differentially expressed in recurrent/progressive tumors with p
- Subjects :
- Proteomics
Original article
Cancer Research
CBTN, Children's Brain Tumor Network
RNA-sequencing
CBTTC, The Children's Brain Tumor Tissue Consortium
Recurrence
GSEA, Gene Set Enrichment Analysis
Databases, Genetic
Exome Sequencing
Biomarkers, Tumor
Humans
Genetic Predisposition to Disease
Child
RC254-282
Progression
Brain Neoplasms
Gene Expression Profiling
CPTAC, Clinical Proteomic Tumor Analysis Consortium
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Computational Biology
Pediatric brain tumors
Mutation
Disease Progression
TCGA, The Cancer Genome Atlas
Disease Susceptibility
Transcriptome
Subjects
Details
- ISSN :
- 14765586
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Neoplasia
- Accession number :
- edsair.doi.dedup.....02bc4607c8eb12123df7a80ad1066097