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Diagnostic Accuracy of Affective Social Tasks in the Clinical Classification Between the Behavioral Variant of Frontotemporal Dementia and Other Neurodegenerative Disease
- Source :
- Journal of Alzheimer's Disease. 80:1401-1411
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- Background: Severe socio-emotional impairments characterize the behavioral variant of frontotemporal dementia (bvFTD). However, literature reports social cognition disorders in other dementias. Objective: In this study, we investigated the accuracy of social cognition performances in the early and differential diagnosis of bvFTD. Methods: We included 131 subjects: 32 bvFTD, 26 Alzheimer’s disease (AD), 16 primary progressive aphasia (PPA), 17 corticobasal syndrome (CBS), and 40 healthy control (HC). Each subject completed the Ekman 60 faces (Ek-60F) test assessing basic emotion recognition and the Story-based Empathy Task (SET) assessing attribution of intentions/emotions. A combined social measure (i.e., Emotion Recognition and Attribution (ERA) index) was calculated. One-way ANOVA has been used to compare performances among groups, while receiver operating characteristic (ROC) curve tested measures ability to distinguish subjects with and without bvFTD. Results: Ek-60F and ERA index scores were significantly lower in bvFTD versus HC, AD, and PPA groups. ROC analyses significantly distinguished bvFTD from HC (AUC 0.82–0.92), with the Ek-60F test showing the highest performance, followed by the ERA index. These two social measures showed the best accuracy in detecting bvFTD from AD (AUC 0.78–0.74) and PPA (AUC 0.80–0.76). Investigated measures failed in detecting bvFTD from CBS. Conclusion: Accuracy analyses support the advantage of using social cognition tests for bvFTD diagnosis. Short social battery may reduce uncertainties and improve disease identification in clinical settings. We recommend a revision of current clinical criteria considering neuropsychological deficits in emotion recognition and processing tasks as key cognitive markers of this neurodegenerative syndrome.
- Subjects :
- Male
media_common.quotation_subject
Emotions
Empathy
Neuropsychological Tests
050105 experimental psychology
Diagnosis, Differential
Social Skills
Primary progressive aphasia
03 medical and health sciences
0302 clinical medicine
Basal Ganglia Diseases
Alzheimer Disease
Social cognition
medicine
Humans
0501 psychology and cognitive sciences
Aged
media_common
Aged, 80 and over
Cerebral Cortex
Receiver operating characteristic
General Neuroscience
05 social sciences
Neuropsychology
Cognition
General Medicine
Middle Aged
medicine.disease
Psychiatry and Mental health
Clinical Psychology
Aphasia, Primary Progressive
ROC Curve
Case-Control Studies
Frontotemporal Dementia
Female
Geriatrics and Gerontology
Psychology
Attribution
030217 neurology & neurosurgery
Clinical psychology
Frontotemporal dementia
Subjects
Details
- ISSN :
- 18758908 and 13872877
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease
- Accession number :
- edsair.doi.dedup.....02be4f2de1ed9803a0417789c42c72ed
- Full Text :
- https://doi.org/10.3233/jad-201210